Sftpb Gene Summary [Rat]
Involved in several processes, including cellular response to mechanical stimulus; cellular response to nitric oxide; and response to dexamethasone. Located in alveolar lamellar body; extracellular space; and multivesicular body. Biomarker of asthma; congenital diaphragmatic hernia; lung disease (multiple); and obesity. Human ortholog(s) of this gene implicated in lung disease (multiple); respiratory syncytial virus infectious disease; and toxic shock syndrome. Orthologous to human SFTPB (surfactant protein B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sftpb |
| Official Name | surfactant protein B [Source:RGD Symbol;Acc:621700] |
| Ensembl ID | ENSRNOG00000010761 |
| Bio databases IDs | |
| Aliases | surfactant protein B |
| Synonyms | AI562151, PSP-B, Pulmonary surfactant protein B, SF-B, SFTB3, SFTP3, SMDP1, SP-B, surfactant associated protein B, surfactant protein B |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Sftpb often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Saposin A-type domain
- Saposin-like type B, region 1
- Saposin-like type B, region 2
- alpha helix
- protein binding
- Saposin (B) Domains
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- acute myeloid leukemia
- organismal death
- pulmonary surfactant metabolism dysfunction type 1
- congenital pulmonary alveolar proteinosis
- thyroid carcinoma
- epithelial thyroid cancer
- metastasis
- cyanosis
- lung adenocarcinoma
role in cell
- expression in
- growth
- invasion by
- phosphorylation in
- binding in
- ubiquitination in
- activation in
- induction
- killing
- size
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- Nucleus
- endosomes
- vesicles
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
- alveolar epithelial lamellar bodies
- endocytotic vesicle
- multivesicular bodies
- exosomes
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Sftpb gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- respiratory gaseous exchange
- sphingolipid metabolic process
- organ morphogenesis
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- clathrin-coated endocytic vesicle
- multivesicular body
- alveolar lamellar body
- extracellular region
- lamellar body
- lysosome
Molecular Function
What the gene product does at the molecular level
- protein binding