Adnp Gene Summary [Rat]
Vasoactive intestinal peptide is a neuroprotective factor that has a stimulatory effect on the growth of some tumor cells and an inhibitory effect on others. This gene encodes a protein that is upregulated by vasoactive intestinal peptide and may be involved in its stimulatory effect on certain tumor cells. The encoded protein contains one homeobox and nine zinc finger domains, suggesting that it functions as a transcription factor. This gene is also upregulated in normal proliferative tissues. Finally, the encoded protein may increase the viability of certain cell types through modulation of p53 activity. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | Adnp |
| Official Name | activity-dependent neuroprotector homeobox [Source:RGD Symbol;Acc:71030] |
| Ensembl ID | ENSRNOG00000010975 |
| Bio databases IDs | |
| Aliases | activity-dependent neuroprotector homeobox |
| Synonyms | activity-dependent neuroprotective protein, activity-dependent neuroprotector homeobox, Adnf, ADNP1, HVDAS, mKIAA0784, MRD28 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Adnp often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- beta-tubulin binding
- copper ion binding
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- peptide binding
- transcription regulator
- Activity-dependent neuroprotector homeobox protein N-terminal
- beta-catenin binding
- nucleic acid binding
- double-stranded DNA binding
- chromatin binding
- protein binding
- sequence-specific DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- prostate cancer
- edema
- Helsmoortel-Van der AA syndrome
- hereditary disorder
- neurodevelopmental disorder
- pervasive developmental disorder
- mental retardation
- epithelial cancer
- global developmental delay
- developmental disorder
role in cell
- cell viability
- expression in
- cell death
- differentiation
- quantity
- apoptosis
- survival
- formation
- adhesion
- outgrowth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Extracellular Space
- chromatin
- perikaryon
- axons
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Adnp gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cGMP-mediated signaling
- neuron differentiation
- nitric oxide homeostasis
- negative regulation of synaptic transmission
- response to carbohydrate stimulus
- positive regulation of canonical Wnt receptor signaling pathway
- positive regulation of axon extension
- regulation of transcription from RNA polymerase II promoter
- negative regulation of neuron apoptotic process
- negative regulation of gene expression
- short-term memory
- negative regulation of protein phosphorylation
- regulation of gene expression
- positive regulation of neuron projection development
- positive regulation of synapse assembly
- neuron apoptotic process
- positive regulation of peptidyl-tyrosine phosphorylation
Cellular Component
Where in the cell the gene product is active
- nucleus
- dendrite
- extracellular space
- neuronal cell body
- chromatin
- axon
Molecular Function
What the gene product does at the molecular level
- protein binding
- copper ion binding
- beta-tubulin binding
- RNA polymerase II regulatory region sequence-specific DNA binding
- peptide binding
- beta-catenin binding
- chromatin binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity