Cntfr Gene Summary [Rat]
Enables ciliary neurotrophic factor receptor activity and cytokine binding activity. Predicted to be involved in ciliary neurotrophic factor-mediated signaling pathway; negative regulation of neuron apoptotic process; and positive regulation of cell population proliferation. Predicted to act upstream of or within several processes, including brainstem development; negative regulation of motor neuron apoptotic process; and suckling behavior. Predicted to be located in apical plasma membrane. Predicted to be part of CNTFR-CLCF1 complex and ciliary neurotrophic factor receptor complex. Predicted to be active in external side of plasma membrane. Orthologous to human CNTFR (ciliary neurotrophic factor receptor). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cntfr |
| Official Name | ciliary neurotrophic factor receptor [Source:RGD Symbol;Acc:1303100] |
| Ensembl ID | ENSRNOG00000047307 |
| Bio databases IDs | |
| Aliases | ciliary neurotrophic factor receptor |
| Synonyms | ciliary neurotrophic factor receptor, CNTFR-alpha, CNTFR-α |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cntfr often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- cytokine binding
- FN3
- immunoglobulin domain
- Immunoglobulin like
- ciliary neurotrophic factor receptor
- protein binding
- receptor binding
- Fibronectin type 3 domain
- transmembrane receptor
Pathways
Biological processes and signaling networks where the Cntfr gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- osteoarthritis
- liver cancer
- epithelial cancer
- colorectal cancer
- hepatocellular carcinoma
- hydronephrosis
- hypothermia
- motor dysfunction
- Waldenström macroglobulinemia
role in cell
- number
- expression in
- proliferation
- growth
- quantity
- apoptosis
- cell death
- phosphorylation in
- differentiation
- survival
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
- apical membrane
- sarcolemma
- perikaryon
- axons
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cntfr gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- sex differentiation
- motor neuron apoptotic process
- signal transduction
- ciliary neurotrophic factor-mediated signaling pathway
- suckling behavior
- positive regulation of cell proliferation
- nervous system development
- brainstem development
- skeletal muscle organ development
- negative regulation of motor neuron apoptotic process
- negative regulation of neuron apoptotic process
Cellular Component
Where in the cell the gene product is active
- CNTFR-CLCF1 complex
- ciliary neurotrophic factor receptor complex
- external side of plasma membrane
- extrinsic to membrane
- plasma membrane
- apical plasma membrane
Molecular Function
What the gene product does at the molecular level
- ciliary neurotrophic factor receptor activity
- protein binding
- receptor binding
- cytokine receptor activity
- cytokine binding