Coq6 Gene Summary [Rat]
Predicted to enable oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen. Predicted to be involved in ubiquinone biosynthetic process. Predicted to be located in mitochondrial inner membrane. Predicted to be part of ubiquinone biosynthesis complex. Predicted to be active in mitochondrion. Predicted to be extrinsic component of mitochondrial inner membrane. Human ortholog(s) of this gene implicated in primary coenzyme Q10 deficiency 6. Orthologous to human COQ6 (coenzyme Q6, monooxygenase). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Coq6 |
| Official Name | coenzyme Q6 monooxygenase [Source:RGD Symbol;Acc:1311149] |
| Ensembl ID | ENSRNOG00000011164 |
| Bio databases IDs | |
| Aliases | coenzyme Q6 monooxygenase |
| Synonyms | 5930427M12Rik, AW742344, CGI-10, coenzyme Q6 monooxygenase, coenzyme Q6, monooxygenase, COQ10D6, D9Mgi31 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Coq6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Rossmann-fold NAD(P)(+)-binding proteins
- Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family
- reduced iron-sulfur:protein oxygen oxidoreductase
- 2-polyprenyl-6-methoxyphenol 4-hydroxylase
- protein binding
- ubiquinone biosynthesis monooxygenase COQ6
- NADH2 or NADPH2 1 atom incorporation:oxygen oxidoreductase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- mitochondrial inner membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Coq6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ubiquinone biosynthetic process
Cellular Component
Where in the cell the gene product is active
- mitochondrion
- Golgi apparatus
- extrinsic to mitochondrial inner membrane
- cell projection
- mitochondrial inner membrane
Molecular Function
What the gene product does at the molecular level
- FAD binding
- protein binding
- oxidoreductase activity
- 2-octaprenyl-6-methoxyphenol hydroxylase activity
- oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen