Cpa3 Gene Summary [Rat]
Predicted to enable metallocarboxypeptidase activity. Predicted to be involved in angiotensin maturation. Predicted to act upstream of or within regulation of angiotensin levels in blood. Predicted to be located in transport vesicle. Predicted to be active in extracellular space. Orthologous to human CPA3 (carboxypeptidase A3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cpa3 |
| Official Name | carboxypeptidase A3 [Source:RGD Symbol;Acc:2390] |
| Ensembl ID | ENSRNOG00000011181 |
| Bio databases IDs | |
| Aliases | carboxypeptidase A3 |
| Synonyms | CARBOXYPEPTIDASE A3, carboxypeptidase A3, mast cell, MC-CPA |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cpa3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc carboxypeptidase
- Zn_pept domain
- peptidase
- metallocarboxypeptidase
- carboxypeptidase A
- M14 family of metallocarboxypeptidases and related proteins
- Carboxypeptidase activation peptide
Pathways
Biological processes and signaling networks where the Cpa3 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hypertension
- diabetic nephropathy
- androgenic alopecia
- eosinophilic esophagitis
- uterine serous papillary cancer
- primary pulmonary hypertension
- anaphylaxis
role in cell
- growth
- abnormal morphology
- integrity
- morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- secretory granules
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cpa3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteolysis
- angiotensin maturation
Cellular Component
Where in the cell the gene product is active
- extracellular space
- secretory granule
- transport vesicle
- extracellular region
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- metallocarboxypeptidase activity