Acy1 Gene Summary [Rat]
Enables aminoacylase activity. Predicted to be involved in protein catabolic process. Predicted to be located in extracellular exosome. Orthologous to human ACY1 (aminoacylase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Acy1 |
| Official Name | aminoacylase 1 [Source:RGD Symbol;Acc:2030] |
| Ensembl ID | ENSRNOG00000011189 |
| Bio databases IDs | |
| Aliases | aminoacylase 1 |
| Synonyms | 1110014J22Rik, Acy1a, Acy1b, ACY1D, AMINOACYLASE, AMINOACYLASE-1, HEL-S-5 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Acy1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc peptidases M18, M20, M28, and M42
- aminoacylase
- Peptidase family M20/M25/M40
- peptidase
- acetylornithine deacetylase or succinyl-diaminopimelate desuccinylase
- succinyl-diaminopimelate desuccinylase, proteobacterial clade
- protein binding
- Peptidase dimerization domain
- identical protein binding
- acetylornithine deacetylase (ArgE)
- N-acyl-L-amino-acid amidohydrolase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- cutaneous melanoma
- hepatocellular carcinoma
- hereditary disorder
- deficiency of aminoacyclase 1
- cholangiocarcinoma
- cholangiocarcinoma cancer
- liver cancer
- cutaneous melanoma cancer
- brain cancer
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
- exosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Acy1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular amino acid metabolic process
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytosol
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- metal ion binding
- aminoacylase activity