Atp1b3 Gene Summary [Rat]
Enables P-type sodium:potassium-exchanging transporter activity. Involved in potassium ion transport and sodium ion transport. Located in apical plasma membrane; basolateral plasma membrane; and caveola. Part of sodium:potassium-exchanging ATPase complex. Orthologous to human ATP1B3 (ATPase Na+/K+ transporting subunit beta 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Atp1b3 |
| Official Name | ATPase Na+/K+ transporting subunit beta 3 [Source:RGD Symbol;Acc:2172] |
| Ensembl ID | ENSRNOG00000011501 |
| Bio databases IDs | |
| Aliases | ATPase Na+/K+ transporting subunit beta 3 |
| Synonyms | ATPase, Na+/K+ transporting, beta 3 polypeptide, ATPase Na+/K+ transporting subunit beta 3, ATPase Na+/K+ transporting subunit β 3, ATPase, Na+/K+ transporting, β 3 polypeptide, ATPB-3, CD298, Na,K-ATPase β subunit 3, NKAB3S |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Atp1b3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ATPase stimulator
- ATPase binding
- protein binding activity, bridging
- Na+/K+-exchanging ATPase
- protein binding
- Sodium / potassium ATPase beta chain
- transporter
Pathways
Biological processes and signaling networks where the Atp1b3 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- liver cancer
- neoplasia
- hepatocellular carcinoma
- diabetic nephropathy
- epithelial cancer
- bipolar disorder
- aortic valve calcification
- lung neoplasm
- appendicitis
- colon neoplasm
role in cell
- growth
- replication in
- expression in
- apoptosis
- cell proliferation
- repolarization
- activation in
- dipeptide repeat protein sensitivity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cell surface
- cellular membrane
- Nucleus
- apical membrane
- caveolae
- basolateral membrane
- sperm tail
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Atp1b3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular potassium ion homeostasis
- potassium ion transmembrane transport
- positive regulation of ATPase activity
- cellular sodium ion homeostasis
- sodium ion transmembrane transport
- membrane repolarization
- protein stabilization
- protein localization in plasma membrane
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- melanosome
- sodium:potassium-exchanging ATPase complex
- sperm flagellum
- basolateral plasma membrane
- apical plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- ATPase activator activity
- protein binding, bridging
- ATPase binding