Cygb Gene Summary [Rat]
Enables heme binding activity; nitric oxide dioxygenase activity, heme protein as donor; and peroxidase activity. Involved in several processes, including negative regulation of collagen biosynthetic process; negative regulation of hepatic stellate cell activation; and nitric oxide catabolic process. Located in cytoplasm. Used to study liver cirrhosis and renal fibrosis. Biomarker of kidney disease and liver cirrhosis. Orthologous to human CYGB (cytoglobin). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cygb |
| Official Name | cytoglobin [Source:RGD Symbol;Acc:69415] |
| Ensembl ID | ENSRNOG00000011541 |
| Bio databases IDs | |
| Aliases | cytoglobin |
| Synonyms | 3110001K20Rik, CYTOGLOBIN, Glnf, HGB, NOD, Staap, STAP |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cygb often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Globin
- oxygen binding
- fatty acid peroxidase
- protein binding
- heme group oxidoreductase
- heme binding
- catalase
- nitrogenous compound oxidoreductase
- superoxide dismutase
- peroxidase
- binding protein
- Globin-like protein superfamily
- transporter
Pathways
Biological processes and signaling networks where the Cygb gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- cognitive impairment
- organismal death
- polycystic kidney disease
- glioma
- glioma formation
role in cell
- production in
- expression in
- proliferation
- apoptosis
- migration
- ferroptosis
- colony formation
- bortezomib sensitivity
- respiration
- peroxidation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
- nuclear speckles
- neurites
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cygb gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to oxidative stress
- negative regulation of collagen biosynthetic process
- response to hypoxia
- fatty acid oxidation
- oxygen transport
- removal of superoxide radicals
- negative regulation of hepatic stellate cell activation
- nitric oxide catabolic process
- negative regulation of fibroblast migration
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
- neuronal cell body
- neuron projection
Molecular Function
What the gene product does at the molecular level
- peroxidase activity
- oxygen binding
- protein binding
- iron ion binding
- oxidoreductase activity
- catalase activity
- fatty acid peroxidase activity
- carbon monoxide binding
- superoxide dismutase activity
- oxygen transporter activity
- heme binding