Kcnd3 Gene Summary [Rat]
Enables A-type (transient outward) potassium channel activity. Involved in cellular response to BMP stimulus; potassium ion export across plasma membrane; and potassium ion import across plasma membrane. Located in several cellular components, including caveola; neuronal cell body; and perinuclear endoplasmic reticulum. Part of voltage-gated potassium channel complex. Human ortholog(s) of this gene implicated in Brugada syndrome 9 and spinocerebellar ataxia type 19/22. Orthologous to human KCND3 (potassium voltage-gated channel subfamily D member 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Kcnd3 |
| Official Name | potassium voltage-gated channel subfamily D member 3 [Source:RGD Symbol;Acc:68394] |
| Ensembl ID | ENSRNOG00000014686 |
| Bio databases IDs | |
| Aliases | potassium voltage-gated channel subfamily D member 3 |
| Synonyms | AW045978, BRGDA9, KCND3L, KCND3S, Kncd3, KSHIVB, KV4.3, LOC684161, potassium voltage-gated channel, Shal-related family, member 3, potassium voltage-gated channel subfamily D member 3, SCA19, SCA22 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Kcnd3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- potassium channel
- voltage-gated potassium channel
- Ion transport protein
- Broad-Complex, Tramtrack and Bric a brac
- BTB_POZ
- Domain of unknown function (DUF3399)
- ion channel binding
- A-type (transient outward) potassium channel
- Shal-type voltage-gated potassium channels, N-terminal
- protein binding
- ion channel
- Polycystin cation channel
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- heart failure
- multiple sclerosis
- ventricular tachycardia
- COVID-19
- epithelial cancer
- spinocerebellar ataxia type 19
- relapsing-remitting multiple sclerosis
- atrial fibrillation
- Brugada syndrome type 9
role in cell
- expression in
- apoptosis
- proliferation
- repolarization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- basal dendrites
- perinuclear region
- cellular membrane
- Nucleus
- reticular perinuclear compartment
- caveolae
- synaptic membrane
- perinuclear space
- synapse
- rough endoplasmatic reticulum
- perikaryon
- dendrites
- apical processes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Kcnd3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- membrane repolarization involved in regulation of cardiac muscle cell action potential
- potassium ion transport
- protein homooligomerization
- regulation of heart rate by cardiac conduction
- regulation of action potential
- membrane repolarization
Cellular Component
Where in the cell the gene product is active
- postsynaptic membrane
- voltage-gated potassium channel complex
- sarcolemma
- dendritic spine
- neuronal cell body
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- voltage-gated potassium channel activity
- protein binding
- metal ion binding
- A-type (transient outward) potassium channel activity
- voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization
- ion channel binding