Icmt Gene Summary [Rat]
Enables protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity. Involved in C-terminal protein methylation; S-adenosylhomocysteine metabolic process; and S-adenosylmethioninamine metabolic process. Predicted to be located in cytoplasmic side of rough endoplasmic reticulum membrane. Predicted to be part of large ribosomal subunit. Predicted to be active in endoplasmic reticulum. Orthologous to human ICMT (isoprenylcysteine carboxyl methyltransferase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Icmt |
| Official Name | isoprenylcysteine carboxyl methyltransferase [Source:RGD Symbol;Acc:621618] |
| Ensembl ID | ENSRNOG00000010953 |
| Bio databases IDs | |
| Aliases | isoprenylcysteine carboxyl methyltransferase |
| Synonyms | 1700008E11RIK, fcmt, Gm13095, HSTE14, isoprenylcysteine carboxyl methyltransferase, MST098, MSTP098, PCCMT, PCMT, PPMT, STE14 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Icmt often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein-S-isoprenylcysteine O-methyltransferase
- cAMP response element binding protein binding
- C-terminal protein carboxyl methyltransferase
- enzyme
- protein binding
- Isoprenylcysteine carboxyl methyltransferase (ICMT) family
Pathways
Biological processes and signaling networks where the Icmt gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- cervical cancer
- metastasis
- epithelial uterine cancer
- tumorigenesis
- abdominal aortic aneurysm
- developmental delay
- cervical small cell carcinoma
- extrapulmonary small cell cancer
role in cell
- growth
- cell viability
- apoptosis
- cell death
- response
- proliferation
- migration
- colony formation
- self-renewal
- association
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- cellular membrane
- ribosome
- Golgi Apparatus
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
- nuclear envelope
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Icmt gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein modification process
- S-adenosylhomocysteine metabolic process
- C-terminal protein methylation
- S-adenosylmethioninamine metabolic process
- protein targeting to membrane
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- membrane
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
- protein C-terminal carboxyl O-methyltransferase activity