Kat2a Gene Summary [Rat]
Enables chromatin binding activity and protein phosphatase binding activity. Involved in several processes, including alpha-tubulin acetylation; intracellular distribution of mitochondria; and positive regulation of cardiac muscle cell differentiation. Located in chromatin. Orthologous to human KAT2A (lysine acetyltransferase 2A). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Kat2a |
| Official Name | lysine acetyltransferase 2A [Source:RGD Symbol;Acc:1307242] |
| Ensembl ID | ENSRNOG00000018364 |
| Bio databases IDs | |
| Aliases | lysine acetyltransferase 2A |
| Synonyms | 1110051E14Rik, GCN5, GCN5L2, hGCN5, K(lysine) acetyltransferase 2A, lysine acetyltransferase 2A, mmGCN5, PCAF-b |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Kat2a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- histone acetyltransferase domain
- histone acetyltransferase
- Acetyltransferase (GNAT) family
- transcription co-activator
- N-acyltransferase
- protein phosphatase binding
- NAT_SF
- transcription factor binding
- histone deacetylase binding
- chromatin binding
- enzyme
- protein binding
- Bromodomain
- ADA2 binding domain
- proline rich domain
- N-acetyltransferase
- PCAF (P300/CBP-associated factor) N-terminal domain
- Acetyltransferase (GNAT) domain
- acetyltransferase
- helix-loop-helix domain
Pathways
Biological processes and signaling networks where the Kat2a gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- systemic lupus erythematosus
- coronary artery disease
- non-small cell lung carcinoma
- non-small cell lung cancer
- muscular atrophy
- exencephaly
- B-cell lymphomagenesis
- inflammatory bowel disease
- growth failure
role in cell
- binding in
- quantity
- expression in
- differentiation
- apoptosis
- growth
- number
- activation
- cell death
- proliferation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- nuclear fraction
- Nucleus
- centrosome
- nucleoplasm
- mitotic spindle
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Kat2a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- multicellular organism growth
- regulation of cartilage development
- telencephalon development
- regulation of DNA repair
- regulation of regulatory T cell differentiation
- negative regulation of gluconeogenesis
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of gluconeogenesis
- fibroblast proliferation
- negative regulation of transcription from RNA polymerase II promoter
- heart development
- regulation of cell division
- chromatin remodeling
- midbrain development
- neural tube closure
- positive regulation of transcription, DNA-dependent
- in utero embryonic development
- internal peptidyl-lysine acetylation
- regulation of synaptic plasticity
- regulation of stem cell maintenance
- cellular response to tumor necrosis factor
- regulation of cell cycle
- gluconeogenesis
- limb development
- regulation of tubulin deacetylation
- regulation of embryonic development
- negative regulation of centriole replication
- regulation of transcription, DNA-dependent
- response to organic cyclic compound
- metencephalon development
- regulation of transcription from RNA polymerase II promoter
- long-term memory
- positive regulation of cardiac muscle cell differentiation
- regulation of protein stability
- somitogenesis
- intracellular distribution of mitochondria
- regulation of RNA splicing
- positive regulation of cytokine production
- response to nutrient levels
- regulation of T cell activation
- positive regulation of cell projection organization
Cellular Component
Where in the cell the gene product is active
- nucleus
- centrosome
- extracellular space
- transcription factor TFTC complex
- mitotic spindle
- oxoglutarate dehydrogenase complex
- SAGA complex
- nucleoplasm
- histone acetyltransferase complex
Molecular Function
What the gene product does at the molecular level
- histone acetyltransferase activity
- H3 histone acetyltransferase activity
- protein phosphatase binding
- protein binding
- transcription coactivator activity
- histone deacetylase binding
- histone acetyltransferase activity (H3-K9 specific)
- histone acetyltransferase activity (H3-K18 specific)
- chromatin binding
- histone acetyltransferase activity (H4-K12 specific)