Ppip5k2 Gene Summary [Rat]
Predicted to enable 5-diphosphoinositol pentakisphosphate 1-kinase activity; ATP binding activity; and inositol hexakisphosphate kinase activity. Predicted to be involved in inositol metabolic process and inositol phosphate biosynthetic process. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 100. Orthologous to human PPIP5K2 (diphosphoinositol pentakisphosphate kinase 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ppip5k2 |
| Official Name | diphosphoinositol pentakisphosphate kinase 2 [Source:RGD Symbol;Acc:1590765] |
| Ensembl ID | ENSRNOG00000011613 |
| Bio databases IDs | |
| Aliases | diphosphoinositol pentakisphosphate kinase 2 |
| Synonyms | CFAP160, D330021B20, DFNB100, diphosphoinositol pentakisphosphate kinase 2, HISPPD1, IP7K2, mKIAA0433, VIP2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ppip5k2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- diphosphoinositol-pentakisphosphate kinase
- phosphate group acceptor phosphotransferase
- inositol-hexakisphosphate kinase
- ATP binding
- Histidine phosphatase superfamily (branch 2)
- protein binding
- Diphosphoinositol pentakisphosphate kinase 2 N-terminal domain
- Histidine phosphatase domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- organismal death
- autosomal recessive deafness type 100
- insomnia
- colorectal carcinoma
- colorectal carcinomagenesis
role in cell
- migration
- proliferation
- binding in
- DNA damage repair in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ppip5k2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- sensory perception of sound
- inositol phosphate biosynthetic process
- inositol phosphate metabolic process
- inositol metabolic process
Cellular Component
Where in the cell the gene product is active
- cytosol
Molecular Function
What the gene product does at the molecular level
- ATP binding
- inositol heptakisphosphate kinase activity
- diphosphoinositol-pentakisphosphate kinase activity
- protein binding
- inositol hexakisphosphate kinase activity
- inositol-1,3,4,5,6-pentakisphosphate kinase activity
- inositol hexakisphosphate 5-kinase activity
- inositol hexakisphosphate 3-kinase activity
- inositol hexakisphosphate 1-kinase activity