Esrp1 Gene Summary [Rat]
Predicted to enable mRNA binding activity. Predicted to be involved in regulation of RNA splicing and regulation of inner ear auditory receptor cell fate specification. Predicted to act upstream of or within alternative mRNA splicing, via spliceosome; morphogenesis of a branching epithelium; and positive regulation of epithelial cell proliferation. Predicted to be located in nuclear body. Predicted to be part of ribonucleoprotein complex. Predicted to be active in nucleoplasm. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 109. Orthologous to human ESRP1 (epithelial splicing regulatory protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Esrp1 |
| Official Name | epithelial splicing regulatory protein 1 [Source:RGD Symbol;Acc:1560481] |
| Ensembl ID | ENSRNOG00000008184 |
| Bio databases IDs | |
| Aliases | epithelial splicing regulatory protein 1 |
| Synonyms | 2210008M09Rik, A630065D16, DFNB109, epithelial splicing regulatory protein 1, RBM35A, RGD1560481, RMB35A |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Esrp1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA recognition motif (RRM) superfamily
- DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily
- RNA recognition motif
- mRNA binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- prostate cancer
- colorectal cancer
- epithelial cancer
- squamous cell lung cancer
- germ cell neoplasia
- non-insulin-dependent diabetes mellitus
- epithelial uterine cancer
- cleft soft palate
- autosomal recessive deafness type 109
role in cell
- proliferation
- expression in
- growth
- invasion by
- migration
- splicing in
- invasion
- differentiation
- motility
- epithelial-mesenchymal transition
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- nucleoplasm
- nuclear bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Esrp1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of auditory receptor cell fate specification
- RNA splicing
- regulation of RNA splicing
- mRNA processing
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear body
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- mRNA binding