Slc2a2 Gene Summary [Rat]
Enables D-glucose transmembrane transporter activity; dehydroascorbic acid transmembrane transporter activity; and insulin receptor binding activity. Involved in several processes, including carbohydrate utilization; dehydroascorbic acid transport; and hexose transmembrane transport. Located in several cellular components, including apical plasma membrane; basolateral plasma membrane; and brush border membrane. Human ortholog(s) of this gene implicated in Fanconi-Bickel syndrome; glycogen storage disease; and type 2 diabetes mellitus. Orthologous to human SLC2A2 (solute carrier family 2 member 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slc2a2 |
| Official Name | solute carrier family 2 member 2 [Source:RGD Symbol;Acc:3705] |
| Ensembl ID | ENSRNOG00000011875 |
| Bio databases IDs | |
| Aliases | solute carrier family 2 member 2 |
| Synonyms | GLUT2, GTT2, Liver/beta cell glucose transporter, Liver/β cell glucose transporter, solute carrier family 2 (facilitated glucose transporter), member 2, solute carrier family 2 member 2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Slc2a2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- hexose transporter
- phosphoglycerate transporter family protein
- insulin receptor binding
- Sugar (and other) transporter
- MFS transporter, sugar porter (SP) family
- Major Facilitator Superfamily
- phosphate:H+ symporter
- galactose transporter
- organic anion transporter
- fructose transporter
- transporter
Pathways
Biological processes and signaling networks where the Slc2a2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- osteoarthritis
- non-insulin-dependent diabetes mellitus
- diabetes mellitus
- hepatocellular carcinoma
- epithelial cancer
- liver cancer
- glycogenosis with glucoaminophosphaturia
- streptozotocin-induced diabetes
- gout
- Alzheimer disease
regulated by
- oleanolic acid
- lipopolysaccharide
- D-glucose
- sirolimus
- LEP
- insulin
- ethanol
- dexamethasone
- (+)-catechin 3-gallate
- INS
role in cell
- apoptosis
- expression in
- differentiation
- phosphorylation in
- cell viability
- generation in
- activation
- response by
- abnormal morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- plasma membrane fraction
- membrane fraction
- cholesterol-rich microdomain
- Cytoplasm
- cell surface
- perinuclear region
- cellular membrane
- endosomes
- vesicles
- intercellular junctions
- apical membrane
- basolateral membrane
- brush border
- detergent-soluble fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Slc2a2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- carbohydrate metabolic process
- dehydroascorbic acid transport
- glucose import
- galactose transport
- positive regulation of insulin secretion involved in cellular response to glucose stimulus
- fructose transport
Cellular Component
Where in the cell the gene product is active
- cell-cell junction
- brush border
- cytoplasm
- membrane
- apical plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- D-glucose transmembrane transporter activity
- dehydroascorbic acid transporter activity
- galactose transmembrane transporter activity
- fructose transmembrane transporter activity
- glucose transmembrane transporter activity
- hexose transmembrane transporter activity