Pck1 Gene Summary [Rat]
Enables several functions, including anion binding activity; manganese ion binding activity; and nucleoside diphosphate kinase activity. Involved in several processes, including cellular response to carbohydrate stimulus; cellular response to peptide hormone stimulus; and cellular response to salt stress. Located in cytoplasm. Used to study type 2 diabetes mellitus. Biomarker of metabolic dysfunction-associated steatohepatitis. Human ortholog(s) of this gene implicated in Alzheimer's disease and type 2 diabetes mellitus. Orthologous to human PCK1 (phosphoenolpyruvate carboxykinase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pck1 |
| Official Name | phosphoenolpyruvate carboxykinase 1 [Source:RGD Symbol;Acc:3267] |
| Ensembl ID | ENSRNOG00000028616 |
| Bio databases IDs | |
| Aliases | phosphoenolpyruvate carboxykinase 1 |
| Synonyms | AI265463, GTP, PCK, PCKDC, PEPCK, PEPCK1, PEPCK-C, phosphoenolpyruvate carboxykinase 1, phosphoenolpyruvate carboxykinase 1, cytosolic, PHOSPHOENOLPYRUVATE CARBOXYKINASE SUPPRESSED BY INSULIN, RATPEPCK |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Pck1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- nucleoside diphosphate kinase
- protein kinase
- phosphoenolpyruvate carboxykinase (GTP)
- regulatory domain
- phosphoenolpyruvate carboxykinase
- Phosphoenolpyruvate carboxykinase C-terminal P-loop domain
- magnesium ion binding
- kinase
- GTP binding
- binding protein
- GDP binding
- Phosphoenolpyruvate carboxykinase N-terminal domain
- PEPCK_HprK
- manganese ion binding
Pathways
Biological processes and signaling networks where the Pck1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hyperglycemia
- epithelial cancer
- epithelial neoplasia
- cancer
- neoplasia
- tumorigenesis
- hepatic fibrosis
- liver cancer
- liver neoplasia
- digestive system cancer
role in cell
- expression in
- production in
- phosphorylation in
- activation in
- binding in
- transcription in
- polyubiquitination in
- ubiquitination in
- cell death
- growth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Endoplasmic Reticulum
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Pck1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to starvation
- glucose metabolic process
- positive regulation of transcription from RNA polymerase II promoter
- cellular response to insulin stimulus
- cellular response to potassium ion starvation
- response to insulin stimulus
- cellular response to fructose stimulus
- cellular hyperosmotic salinity response
- cellular response to glucagon stimulus
- hepatocyte differentiation
- cellular response to glucose stimulus
- glyceraldehyde-3-phosphate biosynthetic process
- cellular response to tumor necrosis factor
- cellular hypotonic salinity response
- response to interleukin-6
- cellular response to hypoxia
- propionate catabolic process
- gluconeogenesis
- glycerol biosynthetic process from pyruvate
- positive regulation of lipid biosynthetic process
- regulation of lipid biosynthetic process
- tricarboxylic acid metabolic process
- oxaloacetate metabolic process
- cellular response to retinoic acid
- positive regulation of memory T cell differentiation
- glucose homeostasis
- cellular response to cAMP
- cellular response to interleukin-1
- response to lipopolysaccharide
- response to activity
- peptidyl-serine phosphorylation
- cellular response to dexamethasone stimulus
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytoplasm
- cytosol
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- carboxylic acid binding
- GTP binding
- magnesium ion binding
- phosphoenolpyruvate carboxykinase (GTP) activity
- GDP binding
- manganese ion binding