Perp Gene Summary [Rat]
Predicted to be involved in several processes, including mammary gland duct morphogenesis; positive regulation of T cell apoptotic process; and positive regulation of neutrophil chemotaxis. Predicted to act upstream of or within several processes, including amelogenesis; desmosome organization; and intrinsic apoptotic signaling pathway by p53 class mediator. Predicted to be located in several cellular components, including Golgi apparatus; desmosome; and mitochondrion. Predicted to be active in cell-cell junction. Human ortholog(s) of this gene implicated in erythrokeratodermia variabilis and mutilating palmoplantar keratoderma with periorificial keratotic plaques. Orthologous to human PERP (p53 apoptosis effector related to PMP22). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Perp |
| Official Name | PERP, TP53 apoptosis effector [Source:RGD Symbol;Acc:1310294] |
| Ensembl ID | ENSRNOG00000011994 |
| Bio databases IDs | |
| Aliases | PERP, TP53 apoptosis effector |
| Synonyms | 1110017A08Rik, dJ496H19.1, EKVP7, ineligibleperp, KCP1, KRTCAP1, OLMS2, p53 apoptosis-associated target, p53 apoptosis effector related to PMP22, PERP, TP53 apoptosis effector, PIGPC1, THW |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Perp often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PMP-22/EMP/MP20/Claudin family
- protein binding
Pathways
Biological processes and signaling networks where the Perp gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- papillomatosis
- epithelial neoplasia
- benign neoplasia
- bulimia nervosa
- organismal death
- Olmsted syndrome type 2
- lung adenocarcinoma
- lung adenocarcinoma formation
- rotator cuff injury
- erythrokeratodermia variabilis et progressiva 7
role in cell
- apoptosis
- cell death
- adhesion
- chemotaxis
- structure
- sensitivity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- Golgi Apparatus
- Mitochondria
- desmosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Perp gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- tissue homeostasis
- Notch signaling pathway
- activation of cysteine-type endopeptidase activity
- desmosome organization
- positive regulation of neutrophil chemotaxis
- signal transduction by p53 class mediator resulting in induction of apoptosis
- mammary gland duct morphogenesis
- positive regulation of T cell apoptotic process
- positive regulation of proteolysis
- heterotypic cell-cell adhesion
- amelogenesis
Cellular Component
Where in the cell the gene product is active
- cell-cell junction
- mitochondrion
- desmosome
- Golgi apparatus
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding