Pinx1 Gene Summary [Rat]
Predicted to enable telomerase RNA binding activity and telomerase inhibitor activity. Predicted to be involved in several processes, including negative regulation of macromolecule metabolic process; positive regulation of protein localization to nucleolus; and protein localization to organelle. Predicted to act upstream of or within telomere maintenance via telomerase. Predicted to be located in several cellular components, including chromosome; nucleoplasm; and spindle. Predicted to be active in nucleolus. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Orthologous to human PINX1 (PIN2 (TERF1) interacting telomerase inhibitor 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pinx1 |
| Official Name | PIN2/TERF1 interacting, telomerase inhibitor 1 [Source:RGD Symbol;Acc:1566025] |
| Ensembl ID | ENSRNOG00000012012 |
| Bio databases IDs | |
| Aliases | PIN2/TERF1 interacting, telomerase inhibitor 1 |
| Synonyms | 2210403I16Rik, 2610028A01Rik, 67-11-3, AC270290.1, CTD-2135J3.4, ENSG00000292296, Gno1, LPTL, LPTS, LPTS1, PIN2 (TERF1) interacting telomerase inhibitor 1, PIN2/TERF1 interacting, telomerase inhibitor 1, Pxr1, RGD1566025 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Pinx1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-patch domain
- binding protein
- enzyme inhibitor activity
- telomerase inhibitory domain
- protein binding
- RNA binding
Pathways
Biological processes and signaling networks where the Pinx1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- epithelial neoplasia
- cancer
- gastrointestinal neoplasia
- digestive system cancer
- non-insulin-dependent diabetes mellitus
- metabolic syndrome X
- atherosclerosis
- systemic lupus erythematosus
- tumorigenesis
role in cell
- activation in
- degradation in
- binding
- binding in
- DNA damage response
- accumulation in
- ubiquitination in
- stabilization in
- processing in
- length
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- spindle apparatus
- Mitochondria
- chromosome
- nucleoplasm
- nucleoli
- kinetochores
- telomeres
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Pinx1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of telomerase activity
- regulation of protein stability
- negative regulation of cell proliferation
- protein localization to chromosome, telomeric region
- telomere maintenance via telomerase
- negative regulation of telomere maintenance via telomerase
- negative regulation of protein ubiquitination
- mitotic metaphase plate congression
- negative regulation of telomerase activity
Cellular Component
Where in the cell the gene product is active
- chromosome, telomeric region
- mitochondrion
- spindle
- nuclear chromosome
- kinetochore
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- telomeric RNA binding
- telomerase inhibitor activity