Cstf3 Gene Summary [Rat]

Predicted to enable mRNA binding activity. Predicted to be involved in co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway. Predicted to be located in nucleoplasm. Predicted to be part of mRNA cleavage stimulating factor complex. Predicted to be active in nucleus. Orthologous to human CSTF3 (cleavage stimulation factor subunit 3). [provided by Alliance of Genome Resources, Jul 2025]

Details

Type
Protein Coding
Official Symbol
Cstf3
Official Name
cleavage stimulation factor subunit 3 [Source:RGD Symbol;Acc:1305901]
Ensembl ID
ENSRNOG00000012089
Bio databases IDs NCBI: 362178 Ensembl: ENSRNOG00000012089
Aliases cleavage stimulation factor subunit 3
Synonyms 4732468G05Rik, cleavage stimulation factor, 3' pre-RNA, subunit 3, cleavage stimulation factor subunit 3, CSTF-77
Species
Rat, Rattus norvegicus
OrthologiesHumanMouse

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cstf3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • HAT (Half-A-TPR) repeats
  • Mad3/BUB1 homology region 1
  • Suppressor of forked protein (Suf)
  • hinge domain
  • protein binding
  • proline rich domain

Pathways

Biological processes and signaling networks where the Cstf3 gene in rat plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • major depression
  • B-cell non-Hodgkin disease
  • pro-B-cell lymphoma
regulated by
  • Bacillus anthracis strain Sterne
  • PTEN
  • DAP3
  • CDK12
  • keratinocytes
  • MMP3
  • SCp2 cells
  • hydroxyurea
regulates
role in cell
  • JQ1-sensitivity

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Nucleus
  • nucleoplasm

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the rat Cstf3 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • RNA 3'-end processing

Cellular Component

Where in the cell the gene product is active
  • nucleus
  • mRNA cleavage stimulating factor complex
  • nucleoplasm

Molecular Function

What the gene product does at the molecular level
  • protein binding
  • RNA binding
  • mRNA binding

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.