Dst Gene Summary [Rat]
Predicted to enable several functions, including integrin binding activity; microtubule plus-end binding activity; and protein homodimerization activity. Predicted to be involved in several processes, including cytoskeleton organization; hemidesmosome assembly; and maintenance of cell polarity. Predicted to act upstream of or within axonogenesis and retrograde axonal transport. Predicted to be located in several cellular components, including cytoskeleton; endoplasmic reticulum; and nucleus. Predicted to be active in several cellular components, including focal adhesion; hemidesmosome; and type III intermediate filament. Predicted to colocalize with intermediate filament. Human ortholog(s) of this gene implicated in epidermolysis bullosa simplex and hereditary sensory and autonomic neuropathy type 6. Orthologous to human DST (dystonin). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dst |
| Official Name | dystonin [Source:RGD Symbol;Acc:1306566] |
| Ensembl ID | ENSRNOG00000012207 |
| Bio databases IDs | |
| Aliases | dystonin |
| Synonyms | 2310001O04Rik, A830042E19RIK, ah, athetoid, BP230, BP240, BPA, Bpag, BPAG1, BPAG1-n, BULLOUS PEMPHIGOID ANTIGEN1, CATX-15, D6S1101, DMH, DT, Dystonin, EBS3, EBSB2, FLJ21489, HSAN6, LOC100506118, LOC100652766, LOC100652827, LOC100996536, MACF2, mKIAA0728, nmf203, nmf339 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Dst often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- helix-rich Mycoplasma protein
- Laminin Domain I
- ERM binding domain
- Tropomyosin
- midsegment 1 domain
- EF hand
- Plectin repeat
- tail domain
- rod domain
- Mitotic checkpoint protein
- SPEC
- Crescentin protein
- chromosome segregation protein SMC, primarily archaeal type
- exonuclease SbcC
- Calponin homology domain
- EF-hand domain pair
- Myosin tail
- EFh
- protein binding
- Alpha helical coiled-coil rod protein (HCR)
- RIM-binding protein of the cytomatrix active zone
- actin-binding domain
- integrin binding
- protein homodimerization
- Coiled-coil domain-containing protein 158
- Intermediate filament protein
- Septation ring formation regulator, EzrA
- Spectrin like domain
- SH3 domain
- Centrosomal colon cancer autoantigen protein family
- Synaptonemal complex protein 1 (SCP-1)
- coiled-coil domain
- chromosome segregation protein SMC, common bacterial type
- EF-hand domain
- Myosin-like coiled-coil protein
- HOOK protein coiled-coil region
- plakin domain
- rad50
- Calcium binding and coiled-coil domain (CALCOCO1) like
- Protein of unknown function (DUF3584)
- Growth-Arrest-Specific Protein 2 Domain
- Domain of unknown function (DUF4659)
- RecF/RecN/SMC N terminal domain
- Spectrin repeats
- intermediate filament binding domain
- calponin homology (CH) domain superfamily
- Spectrin repeat
- Growth-arrest specific micro-tubule binding
- microtubule plus-end binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Charcot-Marie-Tooth disease
- breast ductal carcinoma in situ
- ductal in situ breast cancer
- hereditary disorder
- pancreatic carcinoma
- pancreatic epithelial cancer
- multiple sclerosis
- schizophrenia
- infiltrating ductal breast carcinoma
- invasive ductal breast cancer
role in cell
- expression in
- cell viability
- cell death
- activation in
- degeneration
- accumulation in
- formation
- morphology
- motility
- organization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- detergent resistant lipid raft fraction
- microtubule cytoskeleton
- intermediate filament cytoskeleton
- cytoskeleton
- Cytoplasm
- perinuclear region
- cellular membrane
- focal adhesions
- actin cytoskeleton
- Nucleus
- vesicles
- microtubules
- intermediate filaments
- intercellular junctions
- hemidesmosomes
- sarcomere
- cytosol
- cytoplasmic face of plasma membrane
- reticular perinuclear compartment
- endoplasmic reticulum membrane
- basal membrane
- nucleoplasm
- nuclear envelope
- nuclear scaffolds
- neurites
- axonal rootlet
- sarcolemma
- Z line
- cytoplasmic vesicles
- actin stress fibers
- cell membrane leading edge
- perikaryon
- axons
- dendrites
- postsynaptic density
- basement membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Dst gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell motility
- integrin-mediated signaling pathway
- wound healing
- cytoskeleton organization
- hemidesmosome assembly
- intermediate filament cytoskeleton organization
- response to wounding
- maintenance of cell polarity
- cell adhesion
- retrograde axon cargo transport
Cellular Component
Where in the cell the gene product is active
- microtubule cytoskeleton
- cell leading edge
- microtubule plus end
- intermediate filament
- nucleoplasm
- endoplasmic reticulum membrane
- nuclear envelope
- nucleus
- Z disc
- basal plasma membrane
- basement membrane
- focal adhesion
- cytoplasm
- cell cortex
- membrane
- stress fiber
- H zone
- cytosol
- cytoplasmic vesicle
- hemidesmosome
Molecular Function
What the gene product does at the molecular level
- protein binding
- actin binding
- calcium ion binding
- microtubule plus-end binding
- structural molecule activity
- integrin binding
- microtubule binding