Rdx Gene Summary [Rat]
Enables actin binding activity and protein kinase A binding activity. Involved in several processes, including apical protein localization; barbed-end actin filament capping; and cellular response to platelet-derived growth factor stimulus. Located in several cellular components, including T-tubule; cleavage furrow; and midbody. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 24. Orthologous to human RDX (radixin). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rdx |
| Official Name | radixin [Source:RGD Symbol;Acc:1359472] |
| Ensembl ID | ENSRNOG00000012237 |
| Bio databases IDs | |
| Aliases | radixin |
| Synonyms | DFNB24, radixin |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Rdx often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- FERM central domain
- Band 4.1 homologues
- protein kinase A binding
- Ezrin/radixin/moesin, alpha-helical domain
- Rho gdi binding domain
- cd44 binding domain
- protein domain specific binding
- protein binding
- Pleckstrin homology-like domain
- threonine phosphorylation site
- FERM N-terminal domain
- FERM domain
- ATPase binding
- F-actin binding domain
- actin binding
- Ubl1_cv_Nsp3_N-like
- Ezrin/radixin/moesin family C terminal
- FERM domain B-lobe
- Dbl binding domain
- FERM C-terminal PH-like domain
Pathways
Biological processes and signaling networks where the Rdx gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast cancer
- COVID-19
- neoplasia
- psoriasis
- autosomal recessive deafness type 24
- corneal ulcer
- acute graft-vs-host disease
- Crohn disease
- hearing loss
- familial nonsyndromic hearing impairment
role in cell
- formation
- apoptosis
- proliferation
- migration
- quantity
- cell death
- formation in
- invasiveness
- assembly
- invasion by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- myelin enriched fraction
- cytoskeletal membrane fractions
- ruffle
- cortical actin cytoskeleton
- cell periphery
- apical compartment
- focal adhesions
- cell cortex
- Plasma Membrane
- midbody
- cell-cell contacts
- cytosol
- stereocilia
- apical cell surfaces
- cytoplasmic face of plasma membrane
- membrane ruffles
- apical membrane
- uropod
- growth cone
- transverse tubules
- anchoring junction
- cell tip
- brush border
- cleavage furrow
- membrane tufts
- microvilli
- filopodia
- exosomes
- cell-cell adherens junctions
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Rdx gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of cell shape
- negative regulation of GTPase activity
- positive regulation of G1/S transition of mitotic cell cycle
- regulation of actin filament bundle assembly
- negative regulation of homotypic cell-cell adhesion
- cellular response to platelet-derived growth factor stimulus
- regulation of cell size
- positive regulation of protein catabolic process
- regulation of ruffle assembly
- establishment of endothelial barrier
- cellular response to thyroid hormone stimulus
- barbed-end actin filament capping
- positive regulation of gene expression
- regulation of GTPase activity
- negative regulation of cell size
- apical protein localization
- protein kinase A signaling cascade
- regulation of Rap protein signal transduction
- positive regulation of early endosome to late endosome transport
- protein localization in plasma membrane
- positive regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- cleavage furrow
- plasma membrane
- T-tubule
- extracellular space
- adherens junction
- extracellular vesicular exosome
- focal adhesion
- apical part of cell
- cell tip
- microvillus
- filopodium
- midbody
- cortical actin cytoskeleton
- apical plasma membrane
- lamellipodium
- cell periphery
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA binding
- actin binding
- cadherin binding
- cell adhesion molecule binding
- ATPase binding
- protein kinase A binding