Mmp12 Gene Summary [Rat]
Predicted to enable several functions, including core promoter sequence-specific DNA binding activity; metal ion binding activity; and metalloendopeptidase activity. Involved in several processes, including positive regulation of epithelial cell proliferation; regulation of trophoblast cell migration; and response to hypoxia. Predicted to be located in cytoplasm; extracellular space; and nucleus. Used to study crescentic glomerulonephritis. Biomarker of anti-basement membrane glomerulonephritis and crescentic glomerulonephritis. Human ortholog(s) of this gene implicated in Barrett's esophagus; artery disease (multiple); coronary aneurysm; esophagus adenocarcinoma; and multiple sclerosis. Orthologous to human MMP12 (matrix metallopeptidase 12). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mmp12 |
| Official Name | matrix metallopeptidase 12 [Source:RGD Symbol;Acc:620195] |
| Ensembl ID | ENSRNOG00000030187 |
| Bio databases IDs | |
| Aliases | matrix metallopeptidase 12 |
| Synonyms | HME, macrophage elastase, matrix metallopeptidase 12, ME, METALLOELASTASE, MME, Mmel |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Mmp12 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Hemopexin-like repeats
- Matrixin
- catalytic domain
- nucleic acid binding
- peptidase
- macrophage elastase
- HX
- calcium ion binding
- Zinc-dependent metalloprotease
- sequence-specific DNA binding
- Putative peptidoglycan binding domain
- ZnMc
- endopeptidase
- serine endopeptidase
- zinc ion binding
- double-stranded DNA binding
- collagen binding
- metalloendopeptidase
Pathways
Biological processes and signaling networks where the Mmp12 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Agranulocyte Adhesion and Diapedesis
- Axonal Guidance Signaling
- Bladder Cancer Signaling
- Colorectal Cancer Metastasis Signaling
- Estrogen Receptor Signaling
- Granulocyte Adhesion and Diapedesis
- HIF1α Signaling
- IL-4 Signaling
- Inhibition of Matrix Metalloproteases
- Leukocyte Extravasation Signaling
- Molecular Mechanisms of Cancer
- Osteoarthritis Pathway
- SPINK1 Pancreatic Cancer Pathway
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial neoplasia
- cancer
- epithelial cancer
- chronic obstructive pulmonary disease
- migraines
- osteoarthritis
- abdominal aortic aneurysm
- breast cancer
- psoriasis
- cervical carcinoma
role in cell
- expression in
- proliferation
- activation in
- transcription in
- function
- quantity
- infiltration by
- number
- growth
- migration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Mmp12 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- extracellular matrix disassembly
- positive regulation of epithelial cell proliferation involved in wound healing
- positive regulation of type I interferon-mediated signaling pathway
- negative regulation of type I interferon-mediated signaling pathway
- positive regulation of transcription from RNA polymerase II promoter
- bronchiole development
- negative regulation of transcription from RNA polymerase II promoter
- lung alveolus development
- positive regulation of interferon-alpha production
- elastin catabolic process
- protein import into nucleus
- proteolysis
- regulation of defense response to virus by host
- extracellular matrix organization
- collagen catabolic process
- wound healing, spreading of epidermal cells
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular space
- cytoplasm
- extracellular matrix
- extracellular region
Molecular Function
What the gene product does at the molecular level
- core promoter sequence-specific DNA binding
- zinc ion binding
- collagen binding
- calcium ion binding
- serine-type endopeptidase activity
- endopeptidase activity
- sequence-specific DNA binding
- metalloendopeptidase activity