Abcc2 Gene Summary [Rat]
Enables ABC-type transporter activity; bilirubin transmembrane transporter activity; and protein domain specific binding activity. Involved in several processes, including carboxylic acid transport; cellular response to cytokine stimulus; and cellular response to dexamethasone stimulus. Located in brush border membrane and intracellular canaliculus. Used to study Dubin-Johnson syndrome; bilirubin metabolic disorder; cholestasis; end stage renal disease; and epilepsy. Biomarker of bilirubin metabolic disorder; cholestasis; liver disease (multiple); status epilepticus; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in bilirubin metabolic disorder (multiple); carcinoma (multiple); leukemia (multiple); and liver disease (multiple). Orthologous to human ABCC2 (ATP binding cassette subfamily C member 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Abcc2 |
| Official Name | ATP binding cassette subfamily C member 2 [Source:RGD Symbol;Acc:2366] |
| Ensembl ID | ENSRNOG00000046727 |
| Bio databases IDs | |
| Aliases | ATP binding cassette subfamily C member 2 |
| Synonyms | ABC30, Atpase canalicular type, ATP binding cassette subfamily C member 2, ATP-binding cassette, sub-family member 2, CANALICULAR MULTIDRUG RESISTANCE, CMOAT, cMRP, DJS, Ebcr, mrp, MRP2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Abcc2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Peroxysomal Fatty Acyl CoA Transporter (FAT) Family protein
- conjugate transporter
- nitrate transport ATP-binding subunits C and D
- heme ABC exporter, ATP-binding protein CcmA
- cytoplasmic domain
- energy-coupling factor transporter ATPase
- xenobiotic-transporting ATPase
- toxin transporter
- multi drug resistance-associated protein (MRP)
- nickel import ATP-binding protein NikE
- P-loop containing Nucleoside Triphosphate Hydrolases
- ATPases associated with a variety of cellular activities
- bilirubin transporter
- ATPase activity, coupled to transmembrane movement of substances
- lipid A export permease/ATP-binding protein MsbA
- protein domain specific binding
- protein binding
- organic anion transporter
- inorganic anion transporter
- ABC transporter transmembrane region
- Six-transmembrane helical domain of the ATP-binding cassette transporters
- cystic fibrosis transmembrane conductor regulator (CFTR)
- xenobiotic transporter
- transmembrane domain
- PDZ binding motif
- ABC transporter
- transporter
Pathways
Biological processes and signaling networks where the Abcc2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-small cell lung cancer
- epithelial neoplasia
- cancer
- breast cancer
- liver cancer
- lung cancer
- liver neoplasia
- epithelial cancer
- hereditary disorder
- cholestasis
regulated by
- valproic acid
- cisplatin
- cyclophosphamide
- verlukast
- 17-alpha-ethinylestradiol
- IL1B
- dexamethasone
- lipopolysaccharide
- genistein
- sodium arsenite
regulates
- glutathione
- heavy metal
- p-aminohippuric acid
- hemoglobin
- leukotriene
- troglitazone glucuronide
- irinotecan
- ethinylestradiol-3-o-sulfate
- methotrexate
- ABCC2
role in cell
- growth
- accumulation in
- binding in
- drug resistance
- homeostasis in
- polyglutamylation in
- transport in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- plasma membrane fraction
- membrane vesicles
- membrane fraction
- Cytoplasm
- cell surface
- intracellular space
- apical compartment
- cellular membrane
- Nucleus
- endosomes
- vesicles
- intercellular junctions
- apical cell surfaces
- microsome
- apical membrane
- detergent insoluble microdomains
- brush border
- microvilli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Abcc2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of gene expression
- drug transmembrane transport
- leukotriene transport
- drug export
- transmembrane transport
- xenobiotic metabolic process
- transepithelial transport
- heme catabolic process
- bilirubin transport
- bile acid and bile salt transport
Cellular Component
Where in the cell the gene product is active
- intercellular canaliculus
- plasma membrane
- apical plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- xenobiotic transporter activity
- ATPase activity
- ATP binding
- ATPase activity, coupled to transmembrane movement of substances
- protein binding
- glutathione S-conjugate-exporting ATPase activity
- xenobiotic-transporting ATPase activity
- anion transmembrane-transporting ATPase activity
- organic anion transmembrane transporter activity
- bilirubin transmembrane transporter activity