Basp1 Gene Summary [Rat]
This gene encodes a membrane bound protein with several transient phosphorylation sites and PEST motifs. Conservation of proteins with PEST sequences among different species supports their functional significance. PEST sequences typically occur in proteins with high turnover rates. Immunological characteristics of this protein are species specific. This protein also undergoes N-terminal myristoylation. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Oct 2012]
Details
| Type | Protein Coding |
| Official Symbol | Basp1 |
| Official Name | brain abundant, membrane attached signal protein 1 [Source:RGD Symbol;Acc:621491] |
| Ensembl ID | ENSRNOG00000046313 |
| Bio databases IDs | |
| Aliases | brain abundant, membrane attached signal protein 1 |
| Synonyms | 2610024P12Rik, brain abundant membrane attached signal protein 1, BRAIN-ABUNDANT, MEMBRANE-ATTACHED SIGNAL protein 1, CAP-23, CKAP3, LOC100364588, NAP-22 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Basp1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- calmodulin binding
- double-stranded DNA binding
- nucleic acid binding
- transcription co-repressor
- protein domain specific binding
- protein binding
- sequence-specific DNA binding
- Brain acid soluble protein 1 (BASP1 protein)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- chronic obstructive pulmonary disease
- idiopathic scoliosis
- organismal death
- T-cell non-Hodgkin disease
- mature T-cell neoplasia
- Huntington disease
- hypertrophic scarring
- lung adenocarcinoma
- lung adenocarcinoma formation
- hippocampal atrophy
role in cell
- expression in
- cell viability
- apoptosis
- proliferation
- quantity
- differentiation
- sprouting
- organization
- organization in
- outgrowth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- raft fractions
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- cell junction
- cytoskeleton
- Cytoplasm
- cell surface
- cellular membrane
- Plasma Membrane
- cytosol
- nuclear speckles
- nuclear matrix
- neuromuscular junctions
- growth cone
- PML nuclear bodies
- chromatin
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Basp1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mesenchymal to epithelial transition
- positive regulation of metanephric ureteric bud development
- metanephric mesenchyme development
- positive regulation of heart growth
- gonad development
- negative regulation of transcription, DNA-dependent
- glomerular visceral epithelial cell differentiation
- protein homooligomerization
- thorax and anterior abdomen determination
- diaphragm development
- substantia nigra development
Cellular Component
Where in the cell the gene product is active
- PML body
- nuclear speck
- chromatin
- plasma membrane
- growth cone
- nucleus
- extracellular vesicular exosome
- cytoskeleton
- cytoplasm
- nuclear matrix
- vesicle
- cell junction
- signalosome
Molecular Function
What the gene product does at the molecular level
- calmodulin binding
- protein domain specific binding
- protein binding
- transcription corepressor activity
- transcription regulatory region sequence-specific DNA binding