Slc3a2 Gene Summary [Rat]
Enables neutral L-amino acid transmembrane transporter activity. Involved in carboxylic acid transport; cellular response to glucose starvation; and response to muscle activity. Located in apical plasma membrane and basal plasma membrane. Biomarker of transitional cell carcinoma. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma. Orthologous to human SLC3A2 (solute carrier family 3 member 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slc3a2 |
| Official Name | solute carrier family 3 member 2 [Source:RGD Symbol;Acc:3073] |
| Ensembl ID | ENSRNOG00000018487 |
| Bio databases IDs | |
| Aliases | solute carrier family 3 member 2 |
| Synonyms | 4F2, 4F2HC, 4T2HC, CD98, CD98HC, FRP1, Ly-10, Ly-m10, MDU1, Mgp-2hc, NACAE, solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2, solute carrier family 3 member 2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Slc3a2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- alanine transporter
- leucine transporter
- Alpha amylase, catalytic domain
- protein binding
- aromatic amino acid transporter
- Maltogenic Amylase, C-terminal domain
- neutral amino acid transporter
- Solute carrier family 3 member 2 N-terminus
- Domain of unknown function (DUF3459)
- cytoplasmic domain
- Alpha amylase catalytic domain family
- transmembrane domain
- double-stranded RNA binding
- protein homodimerization
- neutral L-amino acid porter
- protein heterodimerization
- transporter
Pathways
Biological processes and signaling networks where the Slc3a2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- organismal death
- colorectal cancer
- insulin-dependent diabetes mellitus
- androgenic alopecia
- rheumatoid arthritis
- cancer
role in cell
- proliferation
- expression in
- migration
- cell death
- growth
- aggregation
- differentiation
- organization
- fusion
- transformation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- cell pole
- Cytoplasm
- cell surface
- membrane surface
- cellular membrane
- cell-cell contacts
- apical membrane
- basolateral membrane
- basal membrane
- lateral plasma membrane
- nucleoplasm
- synapse
- microsomal membrane
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Slc3a2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- viral entry into host cell
- amino acid transport
- carbohydrate metabolic process
- isoleucine transport
- valine transport
- response to exogenous dsRNA
- tyrosine transport
- calcium ion transport
- tryptophan transport
- sodium ion transmembrane transport
- proline transport
- phenylalanine transport
- methionine transport
- leucine transport
- thyroid hormone transport
Cellular Component
Where in the cell the gene product is active
- apical pole of neuron
- synapse
- plasma membrane
- lysosomal membrane
- cell surface
- nucleoplasm
- basal plasma membrane
- anchoring junction
- extracellular vesicular exosome
- melanosome
- membrane
- basolateral plasma membrane
- apical plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein homodimerization activity
- neutral amino acid transmembrane transporter activity
- neutral L-amino acid secondary active transmembrane transporter activity
- aromatic amino acid transmembrane transporter activity
- L-alanine transmembrane transporter activity
- calcium:sodium antiporter activity
- L-leucine transmembrane transporter activity
- protein binding
- RNA binding
- protein heterodimerization activity
- double-stranded RNA binding
- cadherin binding
- viral receptor activity