Cd44 Gene Summary [Rat]
Enables epidermal growth factor receptor binding activity; phosphoprotein binding activity; and protein kinase binding activity. Involved in several processes, including blood vessel maturation; macrophage fusion; and positive regulation of neutrophil apoptotic process. Located in apical plasma membrane; basolateral plasma membrane; and cell surface. Part of protein-containing complex. Is active in glutamatergic synapse; postsynapse; and presynapse. Biomarker of borna disease and cholestasis. Human ortholog(s) of this gene implicated in breast carcinoma (multiple); carcinoma (multiple); and prostate cancer. Orthologous to human CD44 (CD44 molecule (IN blood group)). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cd44 |
| Official Name | CD44 molecule (Indian blood group) [Source:RGD Symbol;Acc:2307] |
| Ensembl ID | ENSRNOG00000006094 |
| Bio databases IDs | |
| Aliases | CD44 molecule (Indian blood group) |
| Synonyms | 216062 AT, CD44A, CD44 Antigen, CD44 (containing exon 5), Cd44i, CD44 molecule, CD44 molecule (IN blood group), CD44 STANDARD FROM, CDW44, CSPG8, ECM-III, ECMR-III, Epican, H-CAM, HCELL, HERMES, Hermes-1, Hermes antigen, HUTCH-1, HUTCH-I, IN, LHR, Ly-24, MC56, MDU2, MDU3, METAA, MIC4, NKT.44, Pgp-1, RHAMM |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cd44 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- MT1-MMP cleavage site
- extracellular domain
- punt binding
- stem region
- channel regulator
- cargo receptor activity
- protein kinase binding
- cytokine binding
- ectodomain
- epidermal growth factor receptor binding
- phosphoprotein binding
- hyaluronan binding domain
- Extracellular link domain
- protein binding
- ERM binding domain
- Link_Domain
- cytoplasmic domain
- ligand-binding domain
- transmembrane domain
- intracellular domain
- cytosolic tail domain
- cytokine receptor
- hyaluronic acid binding
- transmembrane receptor
Pathways
Biological processes and signaling networks where the Cd44 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-small cell lung cancer
- asthma
- atopic dermatitis
- neoplasia
- superficial papillary bladder carcinoma
- nonmuscle invasive bladder cancer
- bladder carcinoma
- lymphomagenesis
- cancer
- hematologic cancer
role in cell
- inhibition in
- expression in
- binding in
- growth
- aggregation in
- accumulation in
- activation in
- extension
- proliferation
- production in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- detergent-insoluble fractions
- membrane fraction
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- glutaminergic synapse
- Cytoplasm
- presynaptic regions
- cell surface
- cell periphery
- intracellular space
- perinuclear region
- postsynaptic region
- microvesicles
- membrane surface
- cellular membrane
- Nucleus
- vesicles
- Golgi Apparatus
- actin filaments
- intercellular junctions
- desmosomes
- secretory granule membrane
- cytoplasmic aggregates
- cytosol
- apical cell surfaces
- basolateral cell surfaces
- cytoplasmic face of plasma membrane
- plasma membrane extracellular face
- apical membrane
- uropod
- plasma membrane projections
- basolateral membrane
- cell membrane-lagging edges
- ruffled borders
- perinuclear vesicles
- extracellular matrix
- membrane rafts
- cellular protrusions
- microvilli
- filopodia
- plasma
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cd44 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- wound healing, spreading of cells
- cell-matrix adhesion
- negative regulation of DNA damage response, signal transduction by p53 class mediator
- regulation of lamellipodium morphogenesis
- T cell activation
- cellular response to fibroblast growth factor stimulus
- cell adhesion
- positive regulation of monocyte aggregation
- inflammatory response
- cytokine-mediated signaling pathway
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
- negative regulation of apoptotic process
- positive regulation of ERK1 and ERK2 cascade
- positive regulation of heterotypic cell-cell adhesion
- monocyte aggregation
- cell migration
- positive regulation of peptidyl-tyrosine phosphorylation
- hyaluronan catabolic process
- positive regulation of peptidyl-serine phosphorylation
- cartilage development
Cellular Component
Where in the cell the gene product is active
- macrophage migration inhibitory factor receptor complex
- Golgi apparatus
- cell projection
- plasma membrane
- cell surface
- secretory granule membrane
- extracellular vesicular exosome
- focal adhesion
- microvillus
- cytosol
- basolateral plasma membrane
- apical plasma membrane
- lamellipodium membrane
Molecular Function
What the gene product does at the molecular level
- transmembrane signaling receptor activity
- protein binding
- collagen binding
- hyaluronic acid binding
- cytokine receptor activity