Adh6 Gene Summary [Rat]
Enables all-trans-retinol dehydrogenase (NAD+) activity. Involved in several processes, including animal organ regeneration; response to ethanol; and response to progesterone. Predicted to be located in several cellular components, including ciliary basal body; mitochondrion; and nucleoplasm. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in alcohol dependence; late onset Parkinson's disease; and pancreatic cancer. Orthologous to human ADH1A (alcohol dehydrogenase 1A (class I), alpha polypeptide); ADH1B (alcohol dehydrogenase 1B (class I), beta polypeptide); and ADH1C (alcohol dehydrogenase 1C (class I), gamma polypeptide). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Adh6 |
| Official Name | alcohol dehydrogenase 6 (class V) [Source:RGD Symbol;Acc:1306313] |
| Ensembl ID | ENSRNOG00000012436 |
| Bio databases IDs | |
| Aliases | alcohol dehydrogenase 6 (class V) |
| Synonyms | Adh, Adh1, Adh1a, Adh-1e, Adh-1-t, ADH1TL, ADH3, Adh-3e, ADH-A2, ADH-AA, ADH class i, Alcohol dehydrogenase, Alcohol dehydrogenase 1c, alcohol dehydrogenase 1C (class I), gamma polypeptide, alcohol dehydrogenase 1C (class I), γ polypeptide, alcohol dehydrogenase 1 (class I), alcohol deshydrogenase 1, ALDH1C |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Adh6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- alcohol dehydrogenase
- zinc ion binding
- MDR
- Zinc-binding dehydrogenase
- retinol dehydrogenase
- Alcohol dehydrogenase GroES-like domain
- enzyme
- protein binding
- identical protein binding
Pathways
Biological processes and signaling networks where the Adh6 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- liver cancer
- epithelial cancer
- COVID-19
- hepatocellular carcinoma
- weight loss
- late-onset Parkinson disease
- alcoholism
- lung adenocarcinoma
- lung adenocarcinoma formation
- methanol poisoning
role in cell
- dysfunction
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cilia
- intracellular space
- Plasma Membrane
- basal bodies
- Mitochondria
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Adh6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- retinol metabolic process
- retinoic acid metabolic process
Cellular Component
Where in the cell the gene product is active
- cytosol
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- retinol dehydrogenase activity
- alcohol dehydrogenase (NAD) activity
- alcohol dehydrogenase activity, zinc-dependent