Cyc1 Gene Summary [Rat]
Predicted to enable electron transfer activity; heme binding activity; and metal ion binding activity. Involved in response to glucagon. Predicted to be located in mitochondrion. Predicted to be part of respiratory chain complex III. Predicted to be active in mitochondrial inner membrane. Human ortholog(s) of this gene implicated in mitochondrial complex III deficiency nuclear type 6. Orthologous to human CYC1 (cytochrome c1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cyc1 |
| Official Name | cytochrome c-1 [Source:RGD Symbol;Acc:1306597] |
| Ensembl ID | ENSRNOG00000012457 |
| Bio databases IDs | |
| Aliases | cytochrome c-1 |
| Synonyms | 2610002H19Rik, CY1, Cyct1, Cytochrome c1, MC3DN6, UQCR4 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cyc1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Di-haem oxidoreductase, putative peroxidase
- enzyme
- protein binding
- Cytochrome C1 family
Pathways
Biological processes and signaling networks where the Cyc1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Apoptosis Signaling
- CD27 Signaling in Lymphocytes
- Cytotoxic T Lymphocyte-mediated Apoptosis of Target Cells
- Death Receptor Signaling
- Estrogen Receptor Signaling
- Glucocorticoid Receptor Signaling
- Induction of Apoptosis by HIV1
- Lymphotoxin β Receptor Signaling
- Mitochondrial Dysfunction
- Role of PKR in Interferon Induction and Antiviral Response
- Sirtuin Signaling Pathway
- Small Cell Lung Cancer Signaling
- Type I Diabetes Mellitus Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Huntington disease
- systemic juvenile idiopathic arthritis
- mitochondrial disorder
- nuclear type 6 mitochondrial complex III deficiency
- limited systemic sclerosis
regulates
- adenosine triphosphate
role in cell
- survival
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- Nucleus
- Mitochondria
- mitochondrial membrane
- mitochondrial intermembrane space
- mitochondrial inner membrane
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cyc1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular respiration
- response to glucagon stimulus
- mitochondrial electron transport, ubiquinol to cytochrome c
Cellular Component
Where in the cell the gene product is active
- nucleus
- membrane
- mitochondrion
- mitochondrial respiratory chain complex III
- mitochondrial inner membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- ubiquinol-cytochrome-c reductase activity
- metal ion binding
- heme binding