CYC1 Gene Summary [Human]
This gene encodes a subunit of the cytochrome bc1 complex, which plays an important role in the mitochondrial respiratory chain by transferring electrons from the Rieske iron-sulfur protein to cytochrome c. Mutations in this gene may cause mitochondrial complex III deficiency, nuclear type 6. [provided by RefSeq, Dec 2013]
Details
| Type | Retained Intron |
| Official Symbol | CYC1 |
| Official Name | cytochrome c1 [Source:HGNC Symbol;Acc:HGNC:2579] |
| Ensembl ID | ENSG00000179091 |
| Bio databases IDs | |
| Aliases | cytochrome c1 |
| Synonyms | 2610002H19Rik, CY1, Cyct1, Cytochrome c1, MC3DN6, UQCR4 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CYC1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Di-haem oxidoreductase, putative peroxidase
- enzyme
- protein binding
- Cytochrome C1 family
Pathways
Biological processes and signaling networks where the CYC1 gene in human plays a role, providing insight into its function and relevance in health or disease.
- Apoptosis Signaling
- CD27 Signaling in Lymphocytes
- Cytotoxic T Lymphocyte-mediated Apoptosis of Target Cells
- Death Receptor Signaling
- Estrogen Receptor Signaling
- Glucocorticoid Receptor Signaling
- Induction of Apoptosis by HIV1
- Lymphotoxin β Receptor Signaling
- Mitochondrial Dysfunction
- Role of PKR in Interferon Induction and Antiviral Response
- Sirtuin Signaling Pathway
- Small Cell Lung Cancer Signaling
- Type I Diabetes Mellitus Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Huntington disease
- systemic juvenile idiopathic arthritis
- mitochondrial disorder
- nuclear type 6 mitochondrial complex III deficiency
- limited systemic sclerosis
regulates
- adenosine triphosphate
role in cell
- survival
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- Nucleus
- Mitochondria
- mitochondrial membrane
- mitochondrial intermembrane space
- mitochondrial inner membrane
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CYC1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular respiration
- response to glucagon stimulus
- mitochondrial electron transport, ubiquinol to cytochrome c
Cellular Component
Where in the cell the gene product is active
- nucleus
- membrane
- mitochondrion
- mitochondrial respiratory chain complex III
- mitochondrial inner membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- ubiquinol-cytochrome-c reductase activity
- metal ion binding
- heme binding