Ndufaf1 Gene Summary [Rat]
Predicted to enable unfolded protein binding activity. Predicted to be involved in chaperone-mediated protein complex assembly; mitochondrial electron transport, NADH to ubiquinone; and mitochondrial respiratory chain complex I assembly. Predicted to be located in cytosol. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency 11. Orthologous to human NDUFAF1 (NADH:ubiquinone oxidoreductase complex assembly factor 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ndufaf1 |
| Official Name | NADH:ubiquinone oxidoreductase complex assembly factor 1 [Source:RGD Symbol;Acc:1306202] |
| Ensembl ID | ENSRNOG00000005006 |
| Bio databases IDs | |
| Aliases | NADH:ubiquinone oxidoreductase complex assembly factor 1 |
| Synonyms | 2410001M24Rik, CGI-65, CIA30, MC1DN11, NADH:ubiquinone oxidoreductase complex assembly factor 1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ndufaf1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- Complex I intermediate-associated protein 30 (CIA30)
Pathways
Biological processes and signaling networks where the Ndufaf1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- septic shock
- nuclear type 11 mitochondrial complex I deficiency
- cardioencephalomyopathy
- insulin resistance
- mitochondrial disorder
regulates
- reactive oxygen species
- adenosine triphosphate
- Mitochondrial ETC 1
role in cell
- production in
- fragmentation
- activation-induced cell death
- fragmentation in
- tubulation
- tubulation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- cytosol
- mitochondrial inner membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ndufaf1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- macromolecular complex assembly
- mitochondrial electron transport, NADH to ubiquinone
- chaperone-mediated protein complex assembly
- mitochondrial respiratory chain complex I assembly
Cellular Component
Where in the cell the gene product is active
- respiratory chain complex I
- mitochondrial matrix
- mitochondrion
- cytosol
- mitochondrial inner membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- unfolded protein binding