Crh Gene Summary [Rat]
Enables corticotropin-releasing hormone receptor 1 binding activity and corticotropin-releasing hormone receptor 2 binding activity. Involved in several processes, including regulation of macromolecule metabolic process; regulation of secretion by cell; and response to corticosteroid. Located in extracellular space; perikaryon; and varicosity. Is active in neuronal dense core vesicle lumen. Used to study hypoglycemia and obesity. Biomarker of several diseases, including alcohol use disorder; cerebrovascular disease (multiple); extrahepatic cholestasis; sciatic neuropathy; and withdrawal disorder. Human ortholog(s) of this gene implicated in obesity and panic disorder. Orthologous to human CRH (corticotropin releasing hormone). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Crh |
| Official Name | corticotropin releasing hormone [Source:RGD Symbol;Acc:620505] |
| Ensembl ID | ENSRNOG00000012703 |
| Bio databases IDs | |
| Aliases | corticotropin releasing hormone |
| Synonyms | CORTICOTROPIN-RELEASING HORMONE, CRF, Crf2, Crf4, CRH1, Crh-41, Gm1347 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Crh often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Corticotropin-releasing factor family
- G-protein-coupled receptor binding
- alpha helix
- hormone
- protein binding
- receptor binding
- neuropeptide hormone
- cytokine
Pathways
Biological processes and signaling networks where the Crh gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- seizures
- irritable bowel syndrome
- hyperglycemia
- depressive disorder
- acne
- edema
- weight gain
- psoriasis
- neurological disorder
- major depression
role in cell
- expression in
- formation
- accumulation in
- quantity
- proliferation
- apoptosis
- activation
- activation in
- production in
- damage
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- axon component
- secretory granule lumen
- Cytoplasm
- cell surface
- somatodendritic region
- cellular membrane
- Nucleus
- Plasma Membrane
- secretory vesicles
- perikaryon
- axons
- axon terminals
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Crh gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to estrogen stimulus
- locomotory exploration behavior
- regulation of serotonin secretion
- associative learning
- negative regulation of glucagon secretion
- learning or memory
- inflammatory response
- regulation of N-methyl-D-aspartate selective glutamate receptor activity
- long-term synaptic potentiation
- neuron apoptotic process
- synaptic transmission
- positive regulation of cAMP-mediated signaling
- negative regulation of gene expression
- response to corticosterone stimulus
- induction of apoptosis by hormones
- positive regulation of gene expression
- negative regulation of luteinizing hormone secretion
- ion homeostasis
- negative regulation of norepinephrine secretion
- response to immobilization stress
- positive regulation of cell proliferation
- hypothalamus development
- response to xenobiotic stimulus
- response to pain
- response to ethanol
- positive regulation of cortisol secretion
- synaptic transmission, dopaminergic
- response to ether
- positive regulation of corticotropin secretion
- cellular response to cocaine
- positive regulation of corticosterone secretion
- positive regulation of insulin secretion involved in cellular response to glucose stimulus
- adrenal gland development
- lung development
- signal transduction
- negative regulation of systemic arterial blood pressure
- female pregnancy
- negative regulation of circadian sleep/wake cycle, REM sleep
- positive regulation of digestive system process
- positive regulation of calcium ion import
- parturition
- glucocorticoid biosynthetic process
- positive regulation of behavioral fear response
- positive regulation of protein phosphorylation
- positive regulation of circadian sleep/wake cycle, wakefulness
- diterpenoid metabolic process
- cellular response to dexamethasone stimulus
- negative regulation of epinephrine secretion
Cellular Component
Where in the cell the gene product is active
- extracellular space
- varicosity
- synapse
- perikaryon
- extracellular region
Molecular Function
What the gene product does at the molecular level
- corticotropin-releasing hormone receptor 2 binding
- protein binding
- corticotropin-releasing hormone receptor 1 binding
- neuropeptide hormone activity
- corticotropin-releasing hormone activity
- hormone activity
- receptor binding