Crhr2 Gene Summary [Rat]
Enables corticotropin-releasing hormone receptor activity and peptide hormone binding activity. Involved in several processes, including negative regulation of secretion; regulation of intracellular signal transduction; and regulation of macromolecule biosynthetic process. Located in several cellular components, including axon; cell body fiber; and perikaryon. Used to study colitis; ischemia; and muscular atrophy. Biomarker of colitis; depressive disorder; functional colonic disease; and irritable bowel syndrome. Human ortholog(s) of this gene implicated in asthma. Orthologous to human CRHR2 (corticotropin releasing hormone receptor 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Crhr2 |
| Official Name | corticotropin releasing hormone receptor 2 [Source:RGD Symbol;Acc:70547] |
| Ensembl ID | ENSRNOG00000011145 |
| Bio databases IDs | |
| Aliases | corticotropin releasing hormone receptor 2 |
| Synonyms | corticotropin releasing hormone receptor 2, CRF2, CRF2R, CRF-R 2, CRFR2alpha, CRF-RB, HM-CRF, LOC100506602 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Crhr2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- Hormone receptor domain
- 7 transmembrane receptor (Secretin family)
- extracellular domain
- signaling receptor activity
- hormone
- protein binding
- corticotrophin-releasing factor receptor
- seven-transmembrane G protein-coupled receptor superfamily
- polypeptide hormone binding
Pathways
Biological processes and signaling networks where the Crhr2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- obesity
- non-insulin-dependent diabetes mellitus
- early-onset obesity
- insulin resistance
- diabetes mellitus
- hypertension
- acne
- major depression
role in cell
- phosphorylation in
- production in
- expression in
- proliferation
- cell death
- binding
- degradation in
- size
- differentiation
- response
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- axon component
- Cytoplasm
- cell surface
- cellular membrane
- Golgi Apparatus
- Endoplasmic Reticulum
- neurites
- perikaryon
- axons
- dendrites
- axon terminals
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Crhr2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular response to corticotropin-releasing hormone stimulus
- cell surface receptor signaling pathway
- adenylate cyclase-modulating G-protein coupled receptor signaling pathway
- long-term synaptic potentiation
Cellular Component
Where in the cell the gene product is active
- dendrite
- axon terminus
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- G-protein coupled peptide receptor activity
- protein binding
- corticotrophin-releasing factor receptor activity
- peptide hormone binding
- corticotropin-releasing hormone receptor activity