Atox1 Gene Summary [Rat]
Enables ATPase binding activity. Involved in copper ion export; negative regulation of apoptotic process; and response to oxidative stress. Predicted to be active in cytosol. Orthologous to human ATOX1 (antioxidant 1 copper chaperone). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Atox1 |
| Official Name | antioxidant 1 copper chaperone [Source:RGD Symbol;Acc:621684] |
| Ensembl ID | ENSRNOG00000013118 |
| Bio databases IDs | |
| Aliases | antioxidant 1 copper chaperone |
| Synonyms | antioxidant 1 copper chaperone, ATX1, HAH1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Atox1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- copper ion binding
- ATPase binding
- Heavy-metal-associated domain
- copper chaperone
- protein binding
- metallochaperone
- HMA
- transporter
- AXH domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- lung adenocarcinoma
- lung adenocarcinoma formation
- psoriasis
- seizures
- productive infection by HIV-1
role in cell
- survival
- apoptosis
- migration
- expression in
- colony formation
- homeostasis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Atox1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to oxidative stress
- copper ion transport
- cellular copper ion homeostasis
Cellular Component
Where in the cell the gene product is active
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding
- copper ion binding
- metallochaperone activity
- copper chaperone activity
- copper-dependent protein binding