Pdzd2 Gene Summary [Rat]
Predicted to be involved in intracellular signal transduction. Located in several cellular components, including apical part of cell; cell-cell junction; and endoplasmic reticulum. Orthologous to human PDZD2 (PDZ domain containing 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pdzd2 |
| Official Name | PDZ domain containing 2 [Source:RGD Symbol;Acc:619958] |
| Ensembl ID | ENSRNOG00000013140 |
| Bio databases IDs | |
| Aliases | PDZ domain containing 2 |
| Synonyms | 4930537L06Rik, A930022H17Rik, AIPC, Gm21706, Gm82, KIAA0300, LOC100502711, LOC102546845, PAPIN, PDZ domain containing 2, PDZK3, PIN1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Pdzd2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Domain present in PSD-95, Dlg, and ZO-1/2
- canonical PDZ domain
- protein binding
- PDZ domain
- cpPDZ_Deg_HtrA-like
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- chronic obstructive pulmonary disease
- acute myeloid leukemia
- Alzheimer disease
- colorectal cancer
- renal cell carcinoma
- renal cell cancer
- major depression
- bipolar disorder
- systemic lupus erythematosus
- idiopathic scoliosis
role in cell
- expression in
- apoptosis
- degradation in
- S phase
- signal transduction in
- cell proliferation
- aggregation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- intracellular membrane-bounded organelle
- Cytoplasm
- Extracellular Space
- apical compartment
- basal compartment
- Nucleus
- centrosome
- Endoplasmic Reticulum
- intercellular junctions
- cell-cell contacts
- cytosol
- apical membrane
- lateral plasma membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Pdzd2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell adhesion
Cellular Component
Where in the cell the gene product is active
- nucleus
- cell-cell junction
- cytoplasm
- intracellular membrane-bounded organelle
- centriolar satellite
- cytosol
- endoplasmic reticulum
- extracellular region
- plasma membrane