PDZD2 Gene Summary [Human]
The protein encoded by this gene contains six PDZ domains and shares sequence similarity with pro-interleukin-16 (pro-IL-16). Like pro-IL-16, the encoded protein localizes to the endoplasmic reticulum and is thought to be cleaved by a caspase to produce a secreted peptide containing two PDZ domains. In addition, this gene is upregulated in primary prostate tumors and may be involved in the early stages of prostate tumorigenesis. [provided by RefSeq, Dec 2015]
Details
| Type | Processed Transcript |
| Official Symbol | PDZD2 |
| Official Name | PDZ domain containing 2 [Source:HGNC Symbol;Acc:HGNC:18486] |
| Ensembl ID | ENSG00000133401 |
| Bio databases IDs | |
| Aliases | PDZ domain containing 2 |
| Synonyms | 4930537L06Rik, A930022H17Rik, AIPC, Gm21706, Gm82, KIAA0300, LOC100502711, LOC102546845, PAPIN, PDZ domain containing 2, PDZK3, PIN1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PDZD2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Domain present in PSD-95, Dlg, and ZO-1/2
- canonical PDZ domain
- protein binding
- PDZ domain
- cpPDZ_Deg_HtrA-like
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- chronic obstructive pulmonary disease
- acute myeloid leukemia
- Alzheimer disease
- colorectal cancer
- renal cell carcinoma
- renal cell cancer
- major depression
- bipolar disorder
- systemic lupus erythematosus
- idiopathic scoliosis
role in cell
- expression in
- apoptosis
- degradation in
- S phase
- signal transduction in
- cell proliferation
- aggregation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- intracellular membrane-bounded organelle
- Cytoplasm
- Extracellular Space
- apical compartment
- basal compartment
- Nucleus
- centrosome
- Endoplasmic Reticulum
- intercellular junctions
- cell-cell contacts
- cytosol
- apical membrane
- lateral plasma membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PDZD2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell adhesion
Cellular Component
Where in the cell the gene product is active
- nucleus
- cell-cell junction
- cytoplasm
- intracellular membrane-bounded organelle
- centriolar satellite
- cytosol
- endoplasmic reticulum
- extracellular region
- plasma membrane