Mtx2 Gene Summary [Rat]
Predicted to be involved in mitochondrial transport and mitochondrion organization. Predicted to be located in mitochondrion and nucleolus. Predicted to be part of SAM complex. Predicted to be active in cytoplasm. Orthologous to human MTX2 (metaxin 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mtx2 |
| Official Name | metaxin 2 [Source:RGD Symbol;Acc:1306473] |
| Ensembl ID | ENSRNOG00000001559 |
| Bio databases IDs | |
| Aliases | metaxin 2 |
| Synonyms | 1500012G02Rik, MDPS, METAXIN 2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Mtx2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Outer mitochondrial membrane transport complex protein
- Glutathione S-transferase, C-terminal domain
- C-terminal, alpha helical domain of the Glutathione S-transferase family
- Glutathione S-transferase N-terminal domain
- Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
- protein binding
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- ischemic stroke
- anemia
- liver disease
- microalbuminuria
- hypertension
- hyperplasia
- mandibuloacral dysplasia progeroid syndrome
- hypoalbuminemia
- edema
- alopecia
role in cell
- production in
- expression in
- assembly in
- morphology
- function
- fusion
- function in
- adherence
- endocytic capacity
- migratory capacity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- mitochondrial outer membrane
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Mtx2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein import into mitochondrial outer membrane
- mitochondrial transport
- inner mitochondrial membrane organization
- mitochondrion organization
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- mitochondrion
- mitochondrial outer membrane
- nucleolus
- mitochondrial sorting and assembly machinery complex
Molecular Function
What the gene product does at the molecular level
- protein binding