Cpt1a Gene Summary [Rat]
Enables carnitine O-palmitoyltransferase activity and identical protein binding activity. Involved in several processes, including fatty acid metabolic process; liver regeneration; and response to tetrachloromethane. Located in mitochondrial outer membrane. Biomarker of alcoholic hepatitis; end stage renal disease; metabolic dysfunction-associated steatohepatitis; obesity; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in carnitine palmitoyltransferase I deficiency and lipid metabolism disorder. Orthologous to human CPT1A (carnitine palmitoyltransferase 1A). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cpt1a |
| Official Name | carnitine palmitoyltransferase 1A [Source:RGD Symbol;Acc:2396] |
| Ensembl ID | ENSRNOG00000014254 |
| Bio databases IDs | |
| Aliases | carnitine palmitoyltransferase 1A |
| Synonyms | C730027G07, Carnithine palmitoyltransferase I, carnitine palmitoyltransferase 1A, carnitine palmitoyltransferase 1a, liver, Carnitine palmitoyltransferase i, CPT1, CPT-1 alpha, CPT1-L, CPT-1 α, CPTI, CPT-Ia, L-CPT1, Mcpt1, Mitochondrial Carnitine O-palmitoyltransferase1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cpt1a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Choline/Carnitine o-acyltransferase
- protein binding activity, bridging
- carnitine O-palmitoyltransferase
- enzyme
- protein binding
- Carnitine O-palmitoyltransferase N-terminus
- identical protein binding
Pathways
Biological processes and signaling networks where the Cpt1a gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- non-insulin-dependent diabetes mellitus
- systemic lupus erythematosus
- carnitine palmitoyltransferase type I deficiency
- Barrett syndrome
- myelodysplastic syndrome
- myocardial reperfusion injury
- insulin-dependent diabetes mellitus
- low cardiac output
- hereditary disorder
regulates
- adenosine triphosphate
- DNA endogenous promoter
- DNA promoter
- histone H3
- D-glucose
- 32:1 phosphatidylcholine
- long-chain acyl-coenzyme A
- insulin
- CPT1A
- lipid
role in cell
- production in
- cell viability
- proliferation
- invasion by
- migration
- acetylation in
- transmembrane potential
- killing
- differentiation
- killing by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- outer membranes
- cellular membrane
- Mitochondria
- mitochondrial nucleoids
- mitochondrial outer membrane
- nuclear scaffolds
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cpt1a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of fatty acid beta-oxidation
- triglyceride metabolic process
- response to nutrient
- response to alkaloid
- response to organic cyclic compound
- response to xenobiotic stimulus
- glucose metabolic process
- carnitine shuttle
- fatty acid metabolic process
- carnitine metabolic process
- eating behavior
- epithelial cell differentiation
- response to ethanol
- regulation of insulin secretion
- fatty acid beta-oxidation
- long-chain fatty acid metabolic process
- response to hypoxia
- cellular response to fatty acid
- positive regulation of innate immune response
- aflatoxin metabolic process
- regulation of lipid storage
Cellular Component
Where in the cell the gene product is active
- membrane
- mitochondrion
- mitochondrial outer membrane
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- carnitine O-palmitoyltransferase activity
- protein binding, bridging