Ireb2 Gene Summary [Rat]
Enables 4 iron, 4 sulfur cluster binding activity; iron-responsive element binding activity; and regulatory region RNA binding activity. Involved in several processes, including cellular response to epidermal growth factor stimulus; cellular response to iron(III) ion; and response to hypoxia. Located in axon and neuronal cell body. Used to study anemia. Biomarker of anemia; hyperinsulinism; and iron deficiency anemia. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human IREB2 (iron responsive element binding protein 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ireb2 |
| Official Name | iron responsive element binding protein 2 [Source:RGD Symbol;Acc:621539] |
| Ensembl ID | ENSRNOG00000013271 |
| Bio databases IDs | |
| Aliases | iron responsive element binding protein 2 |
| Synonyms | ACO3, D9Ertd85e, IRE-BP 2, IRON binding protein 2, iron responsive element binding protein 2, IRP2, IRP2AD, NDCAMA |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ireb2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Aconitase_swivel
- Aconitase C-terminal domain
- nucleic acid binding
- translation repressor
- heme binding domain
- Aconitase family (aconitate hydratase)
- iron-responsive element binding
- aconitase catalytic domain
- protein binding
- translation regulator
- RNA binding
- aconitate hydratase 1
- binding protein
- nucleic acid binding translation repressor
Pathways
Biological processes and signaling networks where the Ireb2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast cancer
- Alzheimer disease
- schizophrenia
- Crohn disease
- tremor
- colorectal cancer
- microcytic anemia
- chronic obstructive pulmonary disease
- early-onset neurodegeneration with choreoathetoid movements and microcytic anemia
- bradykinesia
role in cell
- expression in
- phosphorylation in
- binding in
- growth
- accumulation in
- abnormal morphology
- number
- oxygen consumption rate
- degeneration
- colony formation by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Golgi Apparatus
- Endoplasmic Reticulum
- cytosol
- perikaryon
- axons
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ireb2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- multicellular organismal iron ion homeostasis
- erythrocyte homeostasis
- post-embryonic development
- citrate metabolic process
- tricarboxylic acid cycle
- protoporphyrinogen IX biosynthetic process
- cellular iron ion homeostasis
- regulation of translation
- osteoclast differentiation
- intestinal absorption
- mRNA stabilization
- establishment of localization in cell
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- mitochondrion
- cytosol
Molecular Function
What the gene product does at the molecular level
- RNA binding
- protein binding
- metal ion binding
- iron-responsive element binding
- 4 iron, 4 sulfur cluster binding
- aconitate hydratase activity