Kcnj8 Gene Summary [Rat]
Enables ATP binding activity; monoatomic cation transmembrane transporter activity; and sulfonylurea receptor binding activity. Involved in kidney development and potassium ion import across plasma membrane. Located in sarcolemma. Part of inward rectifying potassium channel. Is active in glutamatergic synapse and presynaptic active zone membrane. Used to study hypertension. Biomarker of Parkinsonism and sciatic neuropathy. Orthologous to human KCNJ8 (potassium inwardly rectifying channel subfamily J member 8). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Kcnj8 |
| Official Name | potassium inwardly-rectifying channel, subfamily J, member 8 [Source:RGD Symbol;Acc:2960] |
| Ensembl ID | ENSRNOG00000013463 |
| Bio databases IDs | |
| Aliases | potassium inwardly-rectifying channel, subfamily J, member 8 |
| Synonyms | gnite, KIR6.1, potassium inwardly rectifying channel subfamily J member 8, potassium inwardly-rectifying channel, subfamily J, member 8, slmbr, sltr, UKATP1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Kcnj8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- voltage-gated potassium channel
- inward rectifier potassium channel
- cation-transporting ATPase
- Inward rectifier potassium channel C-terminal domain
- Inward rectifier potassium channel transmembrane domain
- ATP-activated inward rectifier potassium channel
- ATP binding
- protein binding
- voltage-gated ion channel
- sulfonylurea receptor binding
- ion channel
Pathways
Biological processes and signaling networks where the Kcnj8 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- liver cancer
- hepatocellular carcinoma
- early repolarization syndrome
- hypertension
- non-insulin-dependent diabetes mellitus
- Brugada syndrome type 1
- idiopathic ventricular fibrillation
- diabetes mellitus
- androgenic alopecia
role in cell
- apoptosis
- phosphorylation in
- proliferation
- differentiation
- activation
- function
- action potential
- transmission
- action potential in
- pyroptosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- presynaptic regions
- cellular membrane
- Mitochondria
- granules
- presynaptic membrane
- synaptosomes
- myofibrils
- sarcolemma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Kcnj8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to cytokine stimulus
- determination of adult lifespan
- atrioventricular node cell differentiation
- response to xenobiotic stimulus
- fat cell differentiation
- vasodilation
- fibroblast proliferation
- potassium ion transport
- heart morphogenesis
- response to ischemia
- synaptic growth at neuromuscular junction
- response to hypoxia
- response to insulin stimulus
- ventricular cardiac muscle tissue development
- fatty acid transport
- kidney development
- response to exogenous dsRNA
- apoptotic process
- regulation of ion transmembrane transport
- calcium ion transmembrane transport
- defense response to virus
- transmission of nerve impulse
- potassium ion transmembrane transport
- p38MAPK cascade
- response to ATP
- neuromuscular process
- coronary vasculature development
- adaptive immune response
- NLRP3 inflammasome complex assembly
- protein secretion
- regulation of blood pressure
- regulation of heart rate
- microglial cell activation
- gene expression
- establishment of cell polarity
- response to lipopolysaccharide
- response to endoplasmic reticulum stress
Cellular Component
Where in the cell the gene product is active
- ATP-sensitive potassium channel complex
- voltage-gated potassium channel complex
- sarcolemma
- presynaptic active zone membrane
- plasma membrane
- potassium ion-transporting ATPase complex
- myofibril
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- cation-transporting ATPase activity
- sulfonylurea receptor binding
- ATP-activated inward rectifier potassium channel activity
- inward rectifier potassium channel activity