Scd Gene Summary [Rat]
Enables iron ion binding activity and stearoyl-CoA 9-desaturase activity. Involved in response to fatty acid; response to nutrient; and unsaturated fatty acid biosynthetic process. Located in membrane. Used to study carcinoma. Biomarker of hyperinsulinism; metabolic dysfunction-associated steatohepatitis; and metabolic dysfunction-associated steatotic liver disease. Orthologous to human SCD (stearoyl-CoA desaturase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Scd |
| Official Name | stearoyl-CoA desaturase [Source:RGD Symbol;Acc:621176] |
| Ensembl ID | ENSRNOG00000013552 |
| Bio databases IDs | |
| Aliases | stearoyl-CoA desaturase |
| Synonyms | ab, Delta9 Desaturase, Scd, Stearoyl-CoA desaturase, stearoyl-Coenzyme A desaturase 1, Stearyl CoA Destaurase |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Scd often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- stearoyl-CoA 9-desaturase
- Membrane-FADS-like
- oxidoreductase
- Fatty acid desaturase
- metal ion binding
- CoA desaturase
- iron ion binding
- enzyme
Pathways
Biological processes and signaling networks where the Scd gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- liver cancer
- hypercholesterolemia
- epithelial cancer
- hyperglycemia
- obesity
- skin barrier defect
- insulin resistance
- weight gain
- hypoplasia
- hepatic steatosis
role in cell
- apoptosis
- quantity
- phosphorylation in
- expression in
- differentiation
- accumulation in
- migration
- activation in
- production in
- number
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- endoplasmic reticulum fraction
- cellular membrane
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
- mitochondria-associated membranes
- nucleoli