Fkbp8 Gene Summary [Rat]
Predicted to enable several functions, including calmodulin binding activity; disordered domain specific binding activity; and identical protein binding activity. Predicted to be involved in several processes, including negative regulation of protein phosphorylation; protein folding; and regulation of mitophagy. Predicted to act upstream of or within several processes, including nervous system development; positive regulation of BMP signaling pathway; and smoothened signaling pathway. Predicted to be located in endoplasmic reticulum membrane and mitochondrion. Predicted to be part of protein-containing complex. Predicted to be active in several cellular components, including cytosol; endomembrane system; and mitochondrial envelope. Orthologous to human FKBP8 (FKBP prolyl isomerase 8). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fkbp8 |
| Official Name | FKBP prolyl isomerase 8 [Source:RGD Symbol;Acc:1308670] |
| Ensembl ID | ENSRNOG00000058359 |
| Bio databases IDs | |
| Aliases | FKBP prolyl isomerase 8 |
| Synonyms | FK506 binding protein 8, FKBP-38, FKBP prolyl isomerase 8, FKBPR38, mFKBP38 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Fkbp8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- FKBP-type peptidyl-prolyl cis-trans isomerase
- TPR repeat
- FK506 binding domain
- calmodulin binding
- Tetratricopeptide repeats
- calmodulin binding domain
- transmembrane domain
- protein domain specific binding
- protein binding
- tetratricopeptide repeat
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- infantile hemangioma formation
- cyanosis
- gastroesophageal reflux
- anophthalmia
- metastasis
- microphthalmia
- clubfoot
- atopic dermatitis
- scoliosis
- exencephaly
role in cell
- cell death
- binding in
- activation in
- specification
- function
- differentiation
- apoptosis
- replication in
- signaling in
- signal transduction in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membranous web
- endoplasmic reticulum mitochondria contact site
- mitochondrial envelope
- intracellular compartment
- Endoplasmic Reticulum
- Mitochondria
- cytosol
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Fkbp8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- multicellular organism growth
- dorsal/ventral neural tube patterning
- smoothened signaling pathway
- protein folding
- positive regulation of BMP signaling pathway
- neuron fate specification
- protein localization in mitochondrion
- negative regulation of protein phosphorylation
- BMP signaling pathway
- negative regulation of apoptotic process
- apoptotic process
- camera-type eye development
- regulation of gene expression
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- mitochondrial membrane
- mitochondrion
- membrane
- cytosol
- endomembrane system
- endoplasmic reticulum
- macromolecular complex
- mitochondrial envelope
Molecular Function
What the gene product does at the molecular level
- calmodulin binding
- identical protein binding
- peptidyl-prolyl cis-trans isomerase activity
- protein binding
- protein binding involved in protein folding
- metal ion binding