Cps1 Gene Summary [Rat]
Enables several functions, including anion binding activity; calcium ion binding activity; and carbamoyl-phosphate synthase (ammonia) activity. Involved in several processes, including cellular response to cAMP; cellular response to glucagon stimulus; and cellular response to oleic acid. Located in cytosol and mitochondrial inner membrane. Part of protein-containing complex. Biomarker of hypertension; obesity; and steatotic liver disease. Human ortholog(s) of this gene implicated in carbamoyl phosphate synthetase I deficiency disease; persistent fetal circulation syndrome; and vascular disease. Orthologous to human CPS1 (carbamoyl-phosphate synthase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cps1 |
| Official Name | carbamoyl-phosphate synthase 1 [Source:RGD Symbol;Acc:2395] |
| Ensembl ID | ENSRNOG00000013704 |
| Bio databases IDs | |
| Aliases | carbamoyl-phosphate synthase 1 |
| Synonyms | 4732433M03, 4732433M03Rik, Carbamoyl Phosphate Synthase, carbamoyl-phosphate synthase 1, carbamoyl-phosphate synthetase 1, Carbamyl Phosphate Synthetase 1, Carbamyl phosphate synthetase i, CPS, CPSASE1, D1Ucla3, GATD6, Hep Par-1, PHN |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cps1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- MGS-like
- GMP synthase (glutamine-hydrolyzing), N-terminal domain or A subunit
- Carbamoyl-phosphate synthase small chain, CPSase domain
- ATP binding
- ATP-grasp in the biosynthetic pathway with Ter operon
- glutamate binding
- enzyme
- D-ala D-ala ligase C-terminus
- Type 1 glutamine amidotransferase (GATase1)-like domain
- MGS-like domain
- carbamoyl-phosphate synthase, small subunit
- phospholipid binding
- Glutamine amidotransferase class-I
- carbamoyl-phosphate synthase (ammonia)
- ATP-grasp domain
- metal ion binding
- calcium ion binding
- Carbamoyl-phosphate synthetase large chain, oligomerization domain
- protein binding
- carbamoyl-phosphate synthase, large subunit
- trpG/papA family
- endopeptidase
- binding protein
- Carbamoyl-phosphate synthase L chain, ATP binding domain
- Carbamoyl-phosphate synthetase large chain, oligomerisation domain
Pathways
Biological processes and signaling networks where the Cps1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- osteoarthritis
- neoplasia
- liver cancer
- liver neoplasia
- epithelial cancer
- glioma formation
- albuminuria
- susceptibility to neonatal pulmonary hypertension
- carbamoyl-phosphate synthase I deficiency
- ornithine transcarbamylase deficiency
regulates
- nitric oxide
- carbamoyl phosphate
- double-stranded DNA
- agar
- triacylglycerol
- ammonia
- homocysteine
- anion
role in cell
- cell viability
- cell death
- colony formation
- response by
- breakage in
- stalling in
- stalling
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- Mitochondria
- cytosol
- mitochondrial matrix
- mitochondrial nucleoids
- mitochondrial inner membrane
- nucleoli
- peroxisomes
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cps1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to food
- carbamoyl phosphate biosynthetic process
- response to zinc ion
- midgut development
- response to starvation
- response to amino acid stimulus
- glutamine metabolic process
- vasodilation
- response to xenobiotic stimulus
- response to toxin
- hepatocyte differentiation
- cellular response to glucagon stimulus
- citrulline biosynthetic process
- response to amine stimulus
- cellular response to fibroblast growth factor stimulus
- response to growth hormone stimulus
- nitric oxide metabolic process
- anion homeostasis
- 'de novo' pyrimidine base biosynthetic process
- urea cycle
- cellular response to ammonium ion
- cellular response to cAMP
- cellular response to oleic acid
- response to lipopolysaccharide
- triglyceride catabolic process
- homocysteine metabolic process
- response to dexamethasone stimulus
Cellular Component
Where in the cell the gene product is active
- mitochondrial matrix
- cytoplasm
- macromolecular complex
- nucleolus
- plasma membrane
- mitochondrial inner membrane
- mitochondrial nucleoid
Molecular Function
What the gene product does at the molecular level
- carbamoyl-phosphate synthase (ammonia) activity
- endopeptidase activity
- small molecule binding
- carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
- phospholipid binding
- modified amino acid binding
- ATP binding
- potassium ion binding
- protein binding
- metal ion binding
- calcium ion binding
- glutamate binding