Crtc3 Gene Summary [Rat]
Predicted to enable cAMP response element binding protein binding activity and transcription coactivator activity. Predicted to be involved in several processes, including cellular response to cAMP; negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway; and regulation of DNA-templated transcription. Predicted to act upstream of or within energy homeostasis and negative regulation of lipid catabolic process. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in cytoplasm and nucleus. Orthologous to human CRTC3 (CREB regulated transcription coactivator 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Crtc3 |
| Official Name | CREB regulated transcription coactivator 3 [Source:RGD Symbol;Acc:1309666] |
| Ensembl ID | ENSRNOG00000011975 |
| Bio databases IDs | |
| Aliases | CREB regulated transcription coactivator 3 |
| Synonyms | 2610312F20RIK, 6332415K15RIK, BC011210, CREB regulated transcription coactivator 3, LOC100909455, LOC107987226, LOC686083, RGD1309666, TORC3 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Crtc3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Transducer of regulated CREB activity middle domain
- Transducer of regulated CREB activity, C terminus
- coiled-coil domain
- protein binding
- Transducer of regulated CREB activity, N terminus
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- obesity
- chronic postoperative pain
- colorectal cancer
- inflammatory bowel disease
- ulcerative colitis
- Crohn disease
- hepatic steatosis
- infection by HIV-1
role in cell
- expression in
- transcription in
- number
- migration
- abnormal morphology
- differentiation
- size
- invasion by
- uptake by
- transactivation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Crtc3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein homotetramerization
- lipid catabolic process
- energy homeostasis
- positive regulation of CREB transcription factor activity
- positive regulation of transcription from RNA polymerase II promoter
- negative regulation of lipid catabolic process
- macrophage activation
- negative regulation of adrenergic receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- cAMP response element binding protein binding
- protein binding