Hsd17b2 Gene Summary [Rat]
Enables estradiol 17-beta-dehydrogenase [NAD(P)+] activity and testosterone dehydrogenase (NAD+) activity. Involved in bone development; cellular response to metal ion; and steroid hormone biosynthetic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in intracellular membrane-bounded organelle. Orthologous to human HSD17B2 (hydroxysteroid 17-beta dehydrogenase 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hsd17b2 |
| Official Name | hydroxysteroid (17-beta) dehydrogenase 2 [Source:RGD Symbol;Acc:621803] |
| Ensembl ID | ENSRNOG00000013982 |
| Bio databases IDs | |
| Aliases | hydroxysteroid (17-beta) dehydrogenase 2 |
| Synonyms | 17beta-HSD Type 2, 17Hsd, AI194836, EDH17B2, HSD17, hydroxysteroid (17-beta) dehydrogenase 2, hydroxysteroid 17-beta dehydrogenase 2, hydroxysteroid (17-β) dehydrogenase 2, hydroxysteroid 17-β dehydrogenase 2, SDR9C2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Hsd17b2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- polyketide synthase keto reductase domain
- Rossmann-fold NAD(P)(+)-binding proteins
- 3alpha(17beta)-hydroxysteroid dehydrogenase (NAD)
- estradiol 17beta-dehydrogenase
- 20alpha-hydroxysteroid dehydrogenase
- pteridine reductase
- enzyme
- protein binding
- Enoyl-(Acyl carrier protein) reductase
- short chain dehydrogenase
Pathways
Biological processes and signaling networks where the Hsd17b2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- growth failure
- endometriosis
- hydrocephalus
- recurrent implantation failure
- breast carcinoma
- colon neoplasm
- colorectal neoplasia
- macrocephaly
- colon cancer
- exencephaly
regulates
- triacylglycerol
- beta-estradiol
- androgen
- testosterone
- androstenedione
- dihydrotestosterone
- estrogen
- sterol
- androstenediol
- 20-alpha-hydroxyprogesterone
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Hsd17b2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- estrogen biosynthetic process
- androgen metabolic process
- response to retinoic acid
- in utero embryonic development
- steroid metabolic process
- placenta development
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- intracellular membrane-bounded organelle
Molecular Function
What the gene product does at the molecular level
- estradiol 17-beta-dehydrogenase activity
- testosterone dehydrogenase (NAD+) activity
- 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity