VDR/RXR Activation
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1alpha,25-dihydroxyvitamin D3 (vitamin D3) is a hormone that plays a crucial role in the regulation/metabolism of calcium and phosphorus in the small intestine, kidney and bone. In addition it is also involved in immune function, tumor suppression, growth regulation and parathyroid hormone secretion. VDR, the vitamin D3 receptor, exists as a heterodimer with RXR. Vitamin D3-bound VDR-RXR, along with other co-activator proteins, mediates the transcriptional regulation of a number of genes. Hence any disruption to the vitamin or its receptor would have consequences in a number of the key physiological processes listed above...
Pathway Summary
1alpha,25-dihydroxyvitamin D3 (vitamin D3) is a hormone that plays a crucial role in the regulation/metabolism of calcium and phosphorus in the small intestine, kidney and bone. In addition it is also involved in immune function, tumor suppression, growth regulation and parathyroid hormone secretion. VDR, the vitamin D3 receptor, exists as a heterodimer with RXR. Vitamin D3-bound VDR-RXR, along with other co-activator proteins, mediates the transcriptional regulation of a number of genes. Hence any disruption to the vitamin or its receptor would have consequences in a number of the key physiological processes listed above.
VDR/RXR Activation Genes list
Explore Genes related to VDR/RXR Activation
BGLAP
Human
bone gamma-carboxyglutamate protein
CAMP
Human
cathelicidin antimicrobial peptide
CDKN1A
Human
cyclin dependent kinase inhibitor 1A
CDKN1B
Human
cyclin dependent kinase inhibitor 1B
CEBPA
Human
CCAAT enhancer binding protein alpha
CEBPB
Human
CCAAT enhancer binding protein beta
COL13A1
Human
collagen type XIII alpha 1 chain
CXCL10
Human
C-X-C motif chemokine ligand 10
CYP24A1
Human
cytochrome P450 family 24 subfamily A member 1
CYP27B1
Human
cytochrome P450 family 27 subfamily B member 1
GADD45A
Human
growth arrest and DNA damage inducible alpha
GTF2B
Human
general transcription factor IIB
HES1
Human
hes family bHLH transcription factor 1
HR
Human
HR lysine demethylase and nuclear receptor corepressor
HSD17B2
Human
hydroxysteroid 17-beta dehydrogenase 2
IGFBP1
Human
insulin like growth factor binding protein 1
IGFBP3
Human
insulin like growth factor binding protein 3
IGFBP5
Human
insulin like growth factor binding protein 5
IGFBP6
Human
insulin like growth factor binding protein 6
PDGFA
Human
platelet derived growth factor subunit A
PPARD
Human
peroxisome proliferator activated receptor delta
PSMC5
Human
proteasome 26S subunit, ATPase 5
RUNX2
Human
RUNX family transcription factor 2
SULT2A1
Human
sulfotransferase family 2A member 1
TGFB2
Human
transforming growth factor beta 2
TRPV5
Human
transient receptor potential cation channel subfamily V member 5
TRPV6
Human
transient receptor potential cation channel subfamily V member 6
Products related to VDR/RXR Activation
Explore products related to VDR/RXR Activation
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