Mbnl2 Gene Summary [Rat]
Predicted to enable RNA binding activity and sequence-specific double-stranded DNA binding activity. Involved in regulation of alternative mRNA splicing, via spliceosome. Predicted to be located in nucleus. Predicted to be active in cytoplasm and nucleoplasm. Orthologous to human MBNL2 (muscleblind like splicing regulator 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mbnl2 |
| Official Name | muscleblind-like splicing regulator 2 [Source:RGD Symbol;Acc:1591755] |
| Ensembl ID | ENSRNOG00000010737 |
| Bio databases IDs | |
| Aliases | muscleblind-like splicing regulator 2 |
| Synonyms | 1110002M11Rik, AI047808, LOC686892, MBLL, MBLL39, mKIAA4072, Muscle blind-like 2, muscleblind like splicing factor 2, muscleblind-like splicing regulator 2, PRO2032 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Mbnl2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- zinc finger
- CCCH-type zinc finger
- double-stranded DNA binding
- Zinc finger C-x8-C-x5-C-x3-H type (and similar)
- protein binding
- sequence-specific DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- seizures
- peripheral arterial disease
- tonic-clonic seizure
- heart disease
- alcoholism
- cardiac fibrosis
- atrial ventricular block
- progressive muscle weakness
- Huntington disease
- squamous-cell carcinoma
role in cell
- expression in
- transmission
- alternative splicing by
- plasticity
- long-term potentiation
- abnormal morphology
- excitatory postsynaptic potential
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Mbnl2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- RNA splicing
- regulation of RNA splicing
- mRNA processing
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- RNA binding
- metal ion binding