Esco1 Gene Summary [Rat]
Predicted to enable identical protein binding activity; protein-lysine-acetyltransferase activity; and zinc ion binding activity. Predicted to be involved in mitotic sister chromatid cohesion; protein acetylation; and regulation of DNA replication. Predicted to be located in chromosome. Predicted to be active in chromatin and nucleus. Orthologous to human ESCO1 (establishment of sister chromatid cohesion N-acetyltransferase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Esco1 |
| Official Name | establishment of sister chromatid cohesion N-acetyltransferase 1 [Source:RGD Symbol;Acc:1596873] |
| Ensembl ID | ENSRNOG00000014031 |
| Bio databases IDs | |
| Aliases | establishment of sister chromatid cohesion N-acetyltransferase 1 |
| Synonyms | A930014I12Rik, CTF, ECO1, EFO1, ESO1, establishment of sister chromatid cohesion N-acetyltransferase 1, LOC682499 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Esco1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- N-acetyltransferase
- zinc ion binding
- zinc-finger of acetyl-transferase ESCO
- ESCO1/2 acetyl-transferase
- enzyme
- acetyltransferase
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- chromosome
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Esco1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- sister chromatid cohesion
- peptidyl-lysine acetylation
- mitotic sister chromatid cohesion
- regulation of DNA replication
- post-translational protein acetylation
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromosome
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- acetyltransferase activity
- N-acetyltransferase activity