Smc3 Gene Summary [Rat]
Predicted to enable several functions, including beta-tubulin binding activity; dynein complex binding activity; and mediator complex binding activity. Involved in meiotic cell cycle. Located in basement membrane and synaptonemal complex. Human ortholog(s) of this gene implicated in Cornelia de Lange syndrome 3; hepatocellular carcinoma; and intellectual disability. Orthologous to human SMC3 (structural maintenance of chromosomes 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Smc3 |
| Official Name | structural maintenance of chromosomes 3 [Source:RGD Symbol;Acc:62006] |
| Ensembl ID | ENSRNOG00000014173 |
| Bio databases IDs | |
| Aliases | structural maintenance of chromosomes 3 |
| Synonyms | BAM, Bamacan, BMH, CDLS3, CSPG6, HCAP, MMIP1, SMC3L1, SmcD, structural maintenance of chromosomes 3 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Smc3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- beta-tubulin binding
- Crescentin protein
- SMC proteins Flexible Hinge Domain
- chromosome segregation protein SMC, primarily archaeal type
- AAA ATPase domain
- nucleic acid binding
- Hyaluronan mediated motility receptor N-terminal
- leucine zipper domain
- chromatin binding
- enzyme
- protein binding
- sequence-specific DNA binding
- phosphorylation site
- AAA domain
- chromosome segregation protein SMC, common bacterial type
- RecF/RecN/SMC N terminal domain
- binding protein
- Trichohyalin-plectin-homology domain
- double-stranded DNA binding
- protein heterodimerization
Pathways
Biological processes and signaling networks where the Smc3 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- acute myeloid leukemia
- myelodysplastic syndrome
- neoplasia
- hepatocellular carcinoma
- hereditary disorder
- non-insulin-dependent diabetes mellitus
- breast adenocarcinoma
- Cornelia de Lange syndrome type 3
- pervasive developmental disorder
- liver cancer
role in cell
- expression in
- phosphorylation in
- proliferation
- formation
- binding in
- survival
- synthesis in
- growth
- cell cycle progression
- transformation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- microtubule aster fraction
- detergent resistant lipid raft fraction
- basal bodies
- cytosol
- connecting cilia
- chromosome
- nucleoplasm
- nucleoli
- spindle pole
- nuclear matrix
- kinetochores
- centromeres
- synaptonemal complexes
- chromatin
- chromosomal axial elements
- basement membrane
- detergent-soluble fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Smc3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- sister chromatid cohesion
- DNA repair
- meiotic cell cycle
- stem cell maintenance
- establishment of meiotic sister chromatid cohesion
- mitotic sister chromatid cohesion
- establishment of mitotic sister chromatid cohesion
- regulation of DNA replication
- mitotic cell cycle
- spindle assembly involved in mitosis
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosol
- nuclear matrix
- lateral element
- cohesin complex
- meiotic cohesin complex
- chromosome
- mitotic cohesin complex
- chromosome, centromeric region
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- microtubule motor activity
- protein binding
- protein heterodimerization activity
- beta-tubulin binding
- mediator complex binding
- double-stranded DNA binding
- dynein complex binding
- chromatin binding