ESCO1 Gene Summary [Human]
Enables identical protein binding activity; peptide-lysine-N-acetyltransferase activity; and zinc ion binding activity. Involved in peptidyl-lysine acetylation; post-translational protein acetylation; and regulation of DNA replication. Located in chromatin. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | ESCO1 |
| Official Name | establishment of sister chromatid cohesion N-acetyltransferase 1 [Source:HGNC Symbol;Acc:HGNC:24645] |
| Ensembl ID | ENSG00000141446 |
| Bio databases IDs | |
| Aliases | establishment of sister chromatid cohesion N-acetyltransferase 1 |
| Synonyms | A930014I12Rik, CTF, ECO1, EFO1, ESO1, establishment of sister chromatid cohesion N-acetyltransferase 1, LOC682499 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ESCO1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- N-acetyltransferase
- zinc ion binding
- zinc-finger of acetyl-transferase ESCO
- ESCO1/2 acetyl-transferase
- enzyme
- acetyltransferase
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- chromosome
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ESCO1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- sister chromatid cohesion
- peptidyl-lysine acetylation
- mitotic sister chromatid cohesion
- regulation of DNA replication
- post-translational protein acetylation
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromosome
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- acetyltransferase activity
- N-acetyltransferase activity