Spart Gene Summary [Rat]
Predicted to enable lipid binding activity and ubiquitin protein ligase binding activity. Predicted to be involved in several processes, including lipophagy; midbody abscission; and negative regulation of BMP signaling pathway. Predicted to act upstream of or within several processes, including adipose tissue development; lipid droplet organization; and negative regulation of collateral sprouting in absence of injury. Predicted to be located in several cellular components, including lipid droplet; midbody; and mitochondrial outer membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in Troyer syndrome. Orthologous to human SPART (spartin). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Spart |
| Official Name | spartin [Source:RGD Symbol;Acc:1305900] |
| Ensembl ID | ENSRNOG00000014155 |
| Bio databases IDs | |
| Aliases | spartin |
| Synonyms | KIAA0610, mKIAA0610, SPARTIN, SPG20, TAHCCP1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Spart often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Microtubule Interacting and Trafficking molecule domain
- ubiquitin protein ligase binding
- lipid binding
- Senescence domain
- MIT
- MIT domain
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- hereditary disorder
- Troyer syndrome
- paresis
- gait disturbance
- esophageal adenocarcinoma
- esophageal carcinoma formation
- motor dysfunction or movement disorder
- ophthalmic disorder
- paraparesis
regulates
- triacylglycerol
- lipid
- EGFR
- uric acid
role in cell
- accumulation in
- number
- delivery
- accumulation
- organization
- migration
- size
- abnormal morphology
- cell division
- cytokinesis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- perinuclear region
- Nucleus
- endosomes
- centrosome
- membrane compartment
- midbody
- postmitotic bridges
- lipid droplets
- cytosol
- trans Golgi network
- mitochondrial outer membrane
- spindle pole
- neurites
- synapse
- membrane processes
- central spindle
- cis Golgi cisternae
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Spart gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- negative regulation of BMP signaling pathway
- abscission
- negative regulation of collateral sprouting in absence of injury
- regulation of mitochondrial membrane potential
- BMP signaling pathway
- neuromuscular process
- collateral sprouting in absence of injury
- lipid particle organization
- adipose tissue development
Cellular Component
Where in the cell the gene product is active
- lipid particle
- cytoplasm
- intracellular membrane-bounded organelle
- cytosol
- synapse
- midbody
- mitochondrial outer membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- ubiquitin protein ligase binding