Klf2 Gene Summary [Rat]
This gene encodes a protein that belongs to the Kruppel family of transcription factors. The encoded zinc finger protein is expressed early in mammalian development and is found in many different cell types. The protein acts to bind the CACCC box found in the promoter of target genes to activate their transcription. It plays a role in many processes during development and disease including adipogenesis, embryonic erythropoiesis, epithelial integrity, inflammation and t-cell viability. [provided by RefSeq, Mar 2017]
Details
| Type | Protein Coding |
| Official Symbol | Klf2 |
| Official Name | Kruppel-like factor 2 [Source:RGD Symbol;Acc:1359220] |
| Ensembl ID | ENSRNOG00000014205 |
| Bio databases IDs | |
| Aliases | Kruppel-like factor 2 |
| Synonyms | KLF transcription factor 2, Kruppel-like transcription factor 2 (lung), LKLF |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Klf2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc finger, C2H2 type
- activation domain
- transcription regulator
- KLF1_2_4_N
- inhibitory domain
- protein binding
- sequence-specific DNA binding
- C2H2-type zinc finger
- DNA binding
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- zinc finger
- double-stranded DNA binding
- Zinc-finger double domain
- zinc finger domain
- transcription factor activity
Pathways
Biological processes and signaling networks where the Klf2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- plasma cell myeloma
- lung cancer
- endometrial cancer
- breast carcinoma
- breast cancer
- edema
- anemia
- epithelial cancer
- renal cancer
- hypertrophic scarring
role in cell
- expression in
- apoptosis
- phosphorylation in
- proliferation
- cell viability
- production in
- signaling in
- differentiation
- binding in
- formation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Klf2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- multicellular organism growth
- positive regulation of nitric oxide biosynthetic process
- cellular response to cycloheximide
- cell morphogenesis
- vasodilation
- positive regulation of transcription from RNA polymerase II promoter
- regulation of gene expression, epigenetic
- erythrocyte maturation
- regulation of transcription from RNA polymerase II promoter
- positive regulation of retinoic acid receptor signaling pathway
- negative regulation of interleukin-6 production
- negative regulation of transcription from RNA polymerase II promoter
- positive regulation of protein metabolic process
- cellular response to fluid shear stress
- positive regulation of transcription, DNA-dependent
- in utero embryonic development
- Type I pneumocyte differentiation
- cellular response to interleukin-1
- cellular response to tumor necrosis factor
- cellular response to laminar fluid shear stress
- cellular response to hydrogen peroxide
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatin
Molecular Function
What the gene product does at the molecular level
- DNA binding
- sequence-specific DNA binding transcription factor activity
- protein binding
- metal ion binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity